{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:13:07Z","timestamp":1785499987745,"version":"3.56.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,5,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Tube\u2010assisted feeding in infancy is common in patients with single\u2010ventricle physiology (\n              <jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content>\n              ). Postnatal brain development is delayed, and injury is common, in patients with\n              <jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content>\n              . The role of brain findings in feeding outcomes remains unclear. We sought to determine the association between neonatal perioperative brain injury and postnatal brain maturation with feeding\u2010tube dependency in patients with\n              <jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content>\n              at neonatal discharge and just before the stage\u20102 palliation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We evaluated a cohort of 48 term neonates with\n              <jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content>\n              who underwent pre\u2010 and postoperative brain magnetic resonance imaging. Perioperative brain injury and microstructural brain development were measured with diffusion tensor imaging including fractional anisotropy in white matter and apparent diffusion coefficient in gray matter. The primary outcome was defined as being 100% orally fed (binary). Of the patients 79% (38\/48) were tube fed at hospital discharge, and 27% (12\/45) were tube fed before stage\u20102 palliation. Perioperative brain injury did not differ by group. Orally fed patients had a faster rate of decrease in apparent diffusion coefficient (3%, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.7% to 4.6%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) at discharge and a faster rate of increase in fractional anisotropy (1.4%, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.6% to 2.2%,\n              <jats:italic>P<\/jats:italic>\n              =0.001) at the time of stage\u20102 palliation compared with tube\u2010fed patients, denoting more robust brain development.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Slower rate of postnatal brain maturation but not perioperative brain injury is associated with feeding modality in infancy. These results support the importance of brain health in optimizing feeding outcomes in patients with\n              <jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.012291","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T09:08:27Z","timestamp":1557392907000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of Perioperative Brain Injury and Development on Feeding Modality in Infants With Single Ventricle Heart Disease"],"prefix":"10.1161","volume":"8","author":[{"given":"Anyir","family":"Hsieh","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Pediatrics University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Tabbutt","sequence":"additional","affiliation":[{"name":"Department of Critical Care University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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