{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:17:34Z","timestamp":1792718254131,"version":"4.5.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,9,17]]},"abstract":"\n Background<\/jats:title>\n \n We have developed a peptide vaccine named\n ATRQ<\/jats:styled-content>\n \u03b2\u2010001, which was proved to retard signal transduction initiated by angiotensin\n II<\/jats:styled-content>\n (Ang II). Ang\n II<\/jats:styled-content>\n was implicated in abdominal aortic aneurysm (\n AAA<\/jats:styled-content>\n ) progression, but whether the\n ATRQ<\/jats:styled-content>\n \u03b2\u2010001 vaccine would prevent\n AAA<\/jats:styled-content>\n is unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Ang\n II<\/jats:styled-content>\n \u2010infused ApoE\n \u2212\/\u2212<\/jats:sup>\n mice and calcium phosphate\u2010induced\n AAA<\/jats:styled-content>\n in C57\n BL<\/jats:styled-content>\n \/6 mice were used to verify the efficiency of\n ATRQ<\/jats:styled-content>\n \u03b2\u2010001 vaccine in\n AAA<\/jats:styled-content>\n . Results demonstrated that the vaccine effectively restrained the aneurysmal dilation and vascular wall destruction of aorta in both animal models, beyond anti\u2010hypertensive effects. In Ang\n II<\/jats:styled-content>\n \u2010induced\n AAA<\/jats:styled-content>\n vascular sections, Immunohistochemical staining showed that the vaccine notably constrained vascular inflammation and vascular smooth muscle cell (\n VSMC<\/jats:styled-content>\n ) phenotypic transition, concurrently reduced macrophages infiltration. In cultured\n VSMC<\/jats:styled-content>\n , the anti\u2010\n ATR<\/jats:styled-content>\n \u2010001 antibody inhibited osteopontin secretion induced by Ang\n II<\/jats:styled-content>\n , thereby impeded macrophage migration while co\u2010culture. Furthermore, metalloproteinases and other matrix proteolytic enzymes were also found to be limited by the vaccine in\u00a0vivo and in\u00a0vitro.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n ATRQ<\/jats:styled-content>\n \u03b2\u2010001 vaccine prevented\n AAA<\/jats:styled-content>\n initiation and progression in both Ang\n II<\/jats:styled-content>\n and calcium phosphate\u2010induced\n AAA<\/jats:styled-content>\n models. And the beneficial effects were played beyond decrease of blood pressure, which provided a novel and promising method to take precautions against\n AAA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.012341","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T09:10:10Z","timestamp":1568279410000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["ATRQ\u03b2\u2010001 Vaccine Prevents Experimental Abdominal Aortic Aneurysms"],"prefix":"10.1161","volume":"8","author":[{"given":"Hongrong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Institute of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Key Laboratory of Biological Targeted Therapy of 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