{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T16:07:02Z","timestamp":1784477222702,"version":"3.55.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,7,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Because family history is a known risk factor for heart disease, it is important to characterize its public health impact in terms of population prevalence of family history of heart disease, the burden of heart disease attributable to family history, and whether family history interacts with modifiable risk factors for heart disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We used population data from NHANES (the National Health and Nutrition Examination Survey [2007\u20132014]) to measure the association of self\u2010reported family history of premature heart disease (\n              <jats:styled-content style=\"fixed-case\">FHPHD<\/jats:styled-content>\n              ) with cardiovascular disease (n=19\u00a0253) and to examine the association between cardiovascular health metrics and\n              <jats:styled-content style=\"fixed-case\">FHPHD<\/jats:styled-content>\n              (n=16\u00a0248). Using logistic regression and multivariable adjustment, family history odds ratios were 5.91 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 3.34\u201310.44) for ages 20 to 39, 3.02 (95% CI, 2.41\u20133.79) for ages 40 to 59, and 1.87 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.54\u20132.28) for age \u226560 for cardiovascular disease. The prevalence of cardiovascular disease for the population with a\n              <jats:styled-content style=\"fixed-case\">FHPHD<\/jats:styled-content>\n              (15.72%; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 13.81\u201317.64) was more than double the prevalence of cardiovascular disease for those without a family history (6.25%; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 5.82\u20136.69). Compared with participants with optimum cardiovascular health, the prevalence ratio for\n              <jats:styled-content style=\"fixed-case\">FHPHD<\/jats:styled-content>\n              was 1.98 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.40\u20132.79) for those with inadequate cardiovascular health.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Millions of people who are at high risk of having cardiovascular disease could be identified using\n              <jats:styled-content style=\"fixed-case\">FHPHD<\/jats:styled-content>\n              .\n              <jats:styled-content style=\"fixed-case\">FHPHD<\/jats:styled-content>\n              can become an important component of public health campaigns that address modifiable risk factors that plan to reduce the overall risk of heart disease.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.012364","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T09:02:05Z","timestamp":1563008525000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Prevalence and Cardiovascular Health Impact of Family History of Premature Heart Disease in the United States: Analysis of the National Health and Nutrition Examination Survey, 2007\u20132014"],"prefix":"10.1161","volume":"8","author":[{"given":"Ramal","family":"Moonesinghe","sequence":"first","affiliation":[{"name":"Office of Minority Health and Health Equity Centers for Disease Control and Prevention Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanhe","family":"Yang","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention National Center for Chronic Disease Prevention and Health Promotion Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention National Center for Chronic Disease Prevention and Health Promotion Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muin J.","family":"Khoury","sequence":"additional","affiliation":[{"name":"Office of Public Health Genomics Centers for Disease Control and Prevention Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.2.239"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.6.1065"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2014.04.007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2013.09.018"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.054"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh237"},{"key":"e_1_3_2_9_2","unstructured":"My Life Check\u2014Life's Simple 7. 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