{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:15:53Z","timestamp":1785338153797,"version":"3.55.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,12,17]]},"abstract":"\n Background<\/jats:title>\n \n Previous studies show that patients with primary aldosteronism are associated with higher risk of congestive heart failure (\n CHF<\/jats:styled-content>\n ). However, the effect of target treatment to the incidental\n CHF<\/jats:styled-content>\n has not been elucidated. We aimed to investigate the risk of new\u2010onset\n CHF<\/jats:styled-content>\n in patients with aldosterone\u2010producing adenomas (\n APAs<\/jats:styled-content>\n ) and explore the effect of adrenalectomy on new onset of\n CHF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n From 1997 to 2009, 688\n APA<\/jats:styled-content>\n were identified and matched with essential hypertension controls. The risks of developing incidental\n CHF<\/jats:styled-content>\n (hazard ratio, 0.49; 95%\n CI<\/jats:styled-content>\n , 0.31\u20130.75;\n P<\/jats:italic>\n =0.001) and mortality (hazard ratio, 0.29; 95%\n CI<\/jats:styled-content>\n , 0.20\u20130.44;\n P<\/jats:italic>\n <0.001) were significantly lower in the\n APA<\/jats:styled-content>\n group after targeted treatment. A total of 605 patients with APAs who underwent adrenalectomy lowered the risks of\n CHF<\/jats:styled-content>\n (subdistribution hazard ratio, 0.55; 95%\n CI<\/jats:styled-content>\n , 0.34\u20130.90;\n P<\/jats:italic>\n =0.017) and mortality (adjusted hazard ratio, 0.27; 95%\n CI<\/jats:styled-content>\n , 0.16\u20130.44;\n P<\/jats:italic>\n <0.001) compared with essential hypertension controls.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In conclusion, for patients with APAs, adrenalectomy can be associated with lower risk of incidental\n CHF<\/jats:styled-content>\n and all\u2010cause mortality in a long\u2010term follow\u2010up.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.012410","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T10:00:25Z","timestamp":1575540025000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Incidental Congestive Heart 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