{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:48:20Z","timestamp":1772628500998,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec id=\"jah34467-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The potential alterations of respiratory pathophysiology after cardiopulmonary resuscitation (\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">CPR<\/jats:styled-content>\n              ) are relatively undefined. While untreated arrest is known to affect post\u2013cardiopulmonary resuscitation circulation, whether it affects respiratory pathophysiology remains unclear. We aimed to investigate the post\u2013cardiopulmonary resuscitation changes in respiratory mechanics and neural respiratory drive with varying delays (5 or 10\u00a0minutes) in the treatment of ventricular fibrillation (\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">VF<\/jats:styled-content>\n              ).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah34467-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Twenty\u2010six male Yorkshire pigs were used. Anesthetized pigs weighing 38\u00b15\u00a0kg were randomized into 3 groups (n=10 each in the\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">VF<\/jats:styled-content>\n              5 and\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">VF<\/jats:styled-content>\n              10 groups, with\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">VF<\/jats:styled-content>\n              kept untreated for 5 and 10\u00a0minutes, respectively, and n=6 in the sham group without\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">VF<\/jats:styled-content>\n              ). Defibrillation was attempted after 6\u00a0minutes of cardiopulmonary resuscitation. Pulse\u2010induced contour cardiac output, respiratory mechanics, diaphragmatic electromyogram, blood gas, lung imaging, and histopathology were evaluated for 12\u00a0hours. Significantly elevated mean root mean square of diaphragmatic electromyogram, transdiaphragmatic pressure, and minute ventilation were observed, but reduced minute ventilation\/mean root mean square, dynamic pulmonary compliance, and Pa\n              <jats:sc>o<\/jats:sc>\n              <jats:sub>2<\/jats:sub>\n              were noted in both\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">VF<\/jats:styled-content>\n              groups. Despite recovery of spontaneous breathing, the abnormalities in respiratory mechanics and\u00a0neural respiratory drive, Pa\n              <jats:sc>o<\/jats:sc>\n              <jats:sub>2<\/jats:sub>\n              , and extravascular lung water continued to last for &gt;12\u00a0hours. The changes in imaging (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.027) and histopathology (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.012) were more severe in the\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">VF<\/jats:styled-content>\n              10 group compared with the VF5 group.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah34467-sec-0003\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">There is an uncoupling between the respiratory center and ventilation after restoration of spontaneous circulation. Prolonged untreated arrest from cardiac arrest contributes to more serious alterations in lung pathophysiology.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.012441","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T09:10:29Z","timestamp":1569316229000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Alterations in Respiratory Mechanics and Neural Respiratory Drive After Restoration of Spontaneous Circulation in a Porcine Model Subjected to Different Downtimes of Cardiac Arrest"],"prefix":"10.1161","volume":"8","author":[{"given":"Zhengfei","family":"Yang","sequence":"first","affiliation":[{"name":"Sun Yat\u2010sen University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houzhen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University","place":["Guangzhou, China"]},{"name":"Shantou Central Hospital","place":["Shantou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingying","family":"Hou","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai","family":"Wen","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Ling","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longyuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanchun","family":"Tang","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University","place":["Guangzhou, China"]},{"name":"Virginia Commonwealth University","place":["Richmond"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2007.12.005"},{"key":"e_1_3_2_3_2","first-page":"L294","article-title":"Intracellular generation of reactive oxygen species during nonhypoxic lung ischemia","volume":"272","author":"Al\u2010Mehdi AB","year":"1997","unstructured":"Al\u2010Mehdi AB, Shuman H, Fisher AB. 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