{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:08:01Z","timestamp":1765807681218,"version":"3.41.2"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The efficacy of nifekalant in preexcited atrial fibrillation (\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              ) has not been assessed.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The study populations consisted of patients with sustained preexcited\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              (n=51), paroxysmal supraventricular tachycardia (n=201), and persistent\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              (n=87). Effects of intravenous infusion of nifekalant were assessed on electrophysiological and clinical parameters. Nifekalant prolonged the shortest preexcited R\u2010R, the average preexcited R\u2010R, and the average R\u2010R intervals from 290\u00b135 to 333\u00b144\u00a0ms, 353\u00b149 to 443\u00b164\u00a0ms, and 356\u00b153 to 467\u00b175\u00a0ms, respectively, in patients with preexcited\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Nifekalant also decreased the percentage of preexcited\n              <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n              complexes, heart rate, and increased systolic pressure (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Nifekalant terminated\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              in 33 of 51 patients (65%). Similar effects were also observed in a subgroup of 12 patients with preexcited\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              and impaired left ventricular function. In patients with paroxysmal supraventricular tachycardia, nifekalant significantly prolonged the effective refractory period, the block cycle length of the antegrade accessory pathway, and the atrial effective refractory period (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Nifekalant had no effect on the effective refractory period of the antegrade atrioventricular node. Finally, in patients with persistent\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              without an accessory pathway, nifekalant did not significantly decrease the ventricular rate of\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              . One patient developed Torsades de Pointes. No other adverse effects were observed.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Nifekalant prolongs the effective refractory period of the antegrade accessory pathway and atrium without blocking antegrade conduction through the atrioventricular node, leading to slowing and\/or to termination of preexcited\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              . Thus, nifekalant might be an effective and a relatively safe drug in patients with preexcited\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.012511","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T12:10:50Z","timestamp":1561464650000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of Nifekalant in Patients With Wolff\u2010Parkinson\u2010White Syndrome and Atrial Fibrillation: Electrophysiological and Clinical Findings"],"prefix":"10.1161","volume":"8","author":[{"given":"Jinzhu","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang of Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang of Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang of Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang of Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianghui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang of Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang of Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zirong","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang of Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Ju","sequence":"additional","affiliation":[{"name":"Post\u2010Anesthetic Care Unit The Second Affiliated Hospital of Nanchang University Nanchang of Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang 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