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TRAF1 (tumor necrosis factor receptor\u2013associated factor 1) is an important adapter protein that is implicated in molecular events regulating immunity, inflammation, and cell death. Little is known about the role and impact of\n              <jats:styled-content style=\"fixed-case\">TRAF<\/jats:styled-content>\n              1 in myocardial I\/R injury.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">TRAF<\/jats:styled-content>\n              1 expression is markedly induced in wild\u2010type mice and cardiomyocytes after I\/R or hypoxia\/reoxygenation stimulation. I\/R models were established in\n              <jats:styled-content style=\"fixed-case\">TRAF<\/jats:styled-content>\n              1 knockout mice and wild type mice (n=10 per group). We demonstrated that\n              <jats:styled-content style=\"fixed-case\">TRAF<\/jats:styled-content>\n              1 deficiency protects against myocardial I\/R\u2013induced loss of heat function, inflammation, and cardiomyocyte death. In addition, overexpression of\n              <jats:styled-content style=\"fixed-case\">TRAF<\/jats:styled-content>\n              1 in primary cardiomyocytes promotes hypoxia\/reoxygenation\u2010induced inflammation and apoptosis in\u00a0vitro. Mechanistically,\n              <jats:styled-content style=\"fixed-case\">TRAF<\/jats:styled-content>\n              1 promotes myocardial I\/R injury through regulating ASK1 (apoptosis signal\u2010regulating kinase 1)\u2013mediated JNK\/p38 (c\u2010Jun N\u2010terminal kinase\/p38) MAPK (mitogen\u2010activated protein kinase) cascades.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Our results indicated that\n              <jats:styled-content style=\"fixed-case\">TRAF<\/jats:styled-content>\n              1 aggravates the development of myocardial I\/R injury by enhancing the activation of\n              <jats:styled-content style=\"fixed-case\">ASK<\/jats:styled-content>\n              1\u2010mediated\n              <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>\n              \/p38 cascades. Targeting the\n              <jats:styled-content style=\"fixed-case\">TRAF<\/jats:styled-content>\n              1\u2013\n              <jats:styled-content style=\"fixed-case\">ASK<\/jats:styled-content>\n              1\u2013\n              <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>\n              \/p38 pathway provide feasible therapies for cardiac I\/R injury.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.012575","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T09:04:08Z","timestamp":1571994248000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["TRAF1 Exacerbates Myocardial Ischemia Reperfusion Injury via ASK1\u2013JNK\/p38 Signaling"],"prefix":"10.1161","volume":"8","author":[{"given":"Weipan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiology Huangshi Central Hospital Affiliated Hospital of Hubei Polytechnic University Edong Healthcare Group Huang Shi China"},{"name":"Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention Huang Shi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Animal Experiment Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Huangshi Central Hospital Affiliated Hospital of Hubei Polytechnic University Edong Healthcare Group Huang Shi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Huangshi Central Hospital Affiliated Hospital of Hubei Polytechnic University Edong Healthcare Group Huang Shi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Huangshi Central Hospital Affiliated Hospital of Hubei Polytechnic University Edong Healthcare Group Huang Shi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoqun","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Huangshi Central Hospital Affiliated Hospital of Hubei Polytechnic University Edong Healthcare Group Huang Shi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe068251"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071667"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00467-8"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.01.013"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.5.H2313"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.08.074"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.1999.tb00099.x"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00434-5"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.863"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2011.07.001"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-70630-6_2"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4733"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(01)00160-7"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602919103"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203812"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e3283557748"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3852"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.411"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt232"},{"key":"e_1_3_1_21_2","first-page":"RA209","article-title":"Oxidative stress and ischemic myocardial syndromes","volume":"15","author":"Misra MK","year":"2009","unstructured":"Misra MK, Sarwat M, Bhakuni P, Tuteja R, Tuteja N. 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