{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:48:05Z","timestamp":1787748485377,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,11,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">As transcatheter aortic valve replacement expands to younger and\/or lower risk patients, the long\u2010term consequences of permanent pacemaker implantation are a concern. Pacemaker dependency and impact have not been methodically assessed in transcatheter aortic valve replacement trials. We report the incidence and predictors of pacemaker implantation and pacemaker dependency after transcatheter aortic valve replacement with the Lotus valve.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 912 patients with high\/extreme surgical risk and symptomatic aortic stenosis were randomized 2:1 (Lotus:CoreValve) in\n              <jats:styled-content style=\"fixed-case\">REPRISE III<\/jats:styled-content>\n              (The Repositionable Percutaneous Replacement of Stenotic Aortic Valve through Implantation of Lotus Valve System\u2014Randomized Clinical Evaluation) trial. Systematic assessment of pacemaker dependency was pre\u2010specified in the trial design. Pacemaker implantation within 30\u00a0days was more frequent with Lotus than CoreValve. By multivariable analysis, predictors of pacemaker implantation included baseline right bundle branch block and depth of implantation; diabetes mellitus was also a predictor with Lotus. No association between new pacemaker implantation and clinical outcomes was found. Pacemaker dependency was dynamic (30\u00a0days: 43%; 1\u00a0year: 50%) and not consistent for individual patients over time. Predictors of pacemaker dependency at 30\u00a0days included baseline right bundle branch block, female sex, and depth of implantation. No differences in mortality or stroke were found between patients who were pacemaker dependent or not at 30\u00a0days. Rehospitalization was higher in patients who were not pacemaker dependent versus patients without a pacemaker or those who were dependent.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Pacemaker implantation was not associated with adverse clinical outcomes. Most patients with a new pacemaker at 30\u00a0days were not dependent at 1\u00a0year. Mortality and stroke were similar between patients with or without pacemaker dependency and patients without a pacemaker.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/\">https:\/\/www.clinicaltrials.gov\/<\/jats:ext-link>\n              . Unique identifier\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              02202434.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.012594","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T09:06:06Z","timestamp":1571821566000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Pacemaker Implantation and Dependency After Transcatheter Aortic Valve Replacement in the REPRISE III Trial"],"prefix":"10.1161","volume":"8","author":[{"given":"Christopher U.","family":"Meduri","sequence":"first","affiliation":[{"name":"Piedmont Heart Institute Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean J.","family":"Kereiakes","sequence":"additional","affiliation":[{"name":"The Christ Hospital Heart and Vascular Center The Lindner Research Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Rajagopal","sequence":"additional","affiliation":[{"name":"Piedmont Heart Institute Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj R.","family":"Makkar","sequence":"additional","affiliation":[{"name":"Cedars\u2014Sinai Heart Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"O'Hair","sequence":"additional","affiliation":[{"name":"Aurora St. Luke's Medical Center Milwaukee WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Linke","sequence":"additional","affiliation":[{"name":"Dresden University Hospital, Heart Center Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Waksman","sequence":"additional","affiliation":[{"name":"Washington Hospital Center Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilis","family":"Babliaros","sequence":"additional","affiliation":[{"name":"Emory University Hospital Emory University Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Stoler","sequence":"additional","affiliation":[{"name":"Baylor Heart &amp; Vascular Hospital Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Mishkel","sequence":"additional","affiliation":[{"name":"St. John's Hospital Springfield IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Rizik","sequence":"additional","affiliation":[{"name":"HonorHealth and the Scottsdale\u2010Lincoln Health Network Scottsdale AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay S.","family":"Iyer","sequence":"additional","affiliation":[{"name":"University at Buffalo\/Gates Vascular Institute Buffalo NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Schindler","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic J.","family":"Allocco","sequence":"additional","affiliation":[{"name":"Boston Scientific Corp Marlborough MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian T.","family":"Meredith","sequence":"additional","affiliation":[{"name":"Boston Scientific Corp Marlborough MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted E.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences Irvine California"},{"name":"Northshore University Health System Evanston Hospital Evanston Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Reardon","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart and Vascular Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028352"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.033"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005514"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19132"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-16-01025"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27463"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.10.016"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.12.128"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.05.030"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2017.09.15"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-017-0580-0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.10.21"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.07.026"},{"key":"e_1_3_2_16_2","unstructured":"Thyregod HGH . 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