{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:03:11Z","timestamp":1792854191403,"version":"4.5.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The aim of the present study was to investigate the efficacy and safety of antiplatelet (aspirin plus cilostazol) dual therapy for patients with noncardioembolic stroke within 48\u00a0hours of symptom onset.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The\n              <jats:styled-content style=\"fixed-case\">ADS<\/jats:styled-content>\n              (Acute Aspirin Plus Cilostazol Dual Therapy for Non\u2010Cardiogenic Stroke Patients Within 48 Hours of Symptom Onset ) study is an investigator\u2010initiated, prospective, multicenter (34 hospitals in Japan), randomized, open\u2010label, and aspirin\u2010controlled trial. Acute stroke patients with noncardioembolic stroke within 48\u00a0hours of onset were studied. The subjects were randomly allocated to combination therapy with aspirin 81 to 200\u00a0mg plus cilostazol 200\u00a0mg (dual group) and single therapy with aspirin 81 to 200\u00a0mg (aspirin group) for 14\u00a0days. After the 14\u00a0days, all patients took the cilostazol 200\u00a0mg for 3\u00a0months. A primary efficacy outcome was defined as any one of the following occurring (neurological deterioration, symptomatic stroke recurrence, or transient ischemic attack) within 14\u00a0days. A primary safety outcome included intracerebral hemorrhage and subarachnoid hemorrhage. Between May 2011 and June 2017, 1201 patients (796 [66%] men; median age, 69 [61\u201377] years) randomized 1:1 to either the dual group or the aspirin group were analyzed. Initial National Institutes of Health Stroke Scale score was 2 (1\u20134) in both groups (\n              <jats:italic>P<\/jats:italic>\n              =0.830). A primary efficacy outcome was observed in 11% in the dual group and 11% in the aspirin group (\n              <jats:italic>P<\/jats:italic>\n              =0.853). A primary safety outcome occurred in 2 (0.3%) in the dual group and in 1 (0.2%) in the aspirin group (\n              <jats:italic>P<\/jats:italic>\n              =0.624).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Dual antiplatelet therapy using cilostazol and aspirin was safe but did not reduce the rate of short\u2010term neurological worsening.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              : umin.ac.jp\/ctr\/index\/htm. Unique identifier:\n              <jats:styled-content style=\"fixed-case\">UMIN<\/jats:styled-content>\n              000004950.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.012652","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T09:08:08Z","timestamp":1564132088000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Acute Aspirin Plus Cilostazol Dual Therapy for Noncardioembolic Stroke Patients Within 48 Hours of Symptom Onset"],"prefix":"10.1161","volume":"8","author":[{"given":"Junya","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Neurological Science Graduate School of Medicine Nippon Medical School Tokyo Japan"},{"name":"Department of Stroke Medicine Kawasaki Medical School Okayama 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