{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:30:26Z","timestamp":1776511826525,"version":"3.51.2"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,11,5]]},"abstract":"\n Background<\/jats:title>\n \n There are limited data about cardiac resynchronization therapy (\n CRT<\/jats:styled-content>\n ) in adult congenital heart disease. We aimed to assess early and late outcomes of\n CRT<\/jats:styled-content>\n among patients with adult congenital heart disease.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We retrospectively studied 54 patients with adult congenital heart disease (median age, 46\u00a0years; range, 18\u201373\u00a0years; 74% men) who received\n CRT<\/jats:styled-content>\n implantation (biventricular paced >90%) between 2004 and 2017. Clinical and echocardiographic data were analyzed at baseline and early (mean\u00b1SD: 1.8\u00b10.8\u00a0years) and late (4.7\u00b10.8\u00a0years) follow\u2010up after\n CRT<\/jats:styled-content>\n . Compared with baseline,\n CRT<\/jats:styled-content>\n was associated with significant improvement at early follow\u2010up in New York Heart Association functional class,\n QRS<\/jats:styled-content>\n duration, and cardiothoracic ratio (\n P<\/jats:italic>\n <0.05 for all); improvement in New York Heart Association class was sustained at late follow\u2010up. Among patients with a systemic left ventricle (\n LV<\/jats:styled-content>\n ; n=39), there was significant increase in\n LV<\/jats:styled-content>\n ejection fraction and reduction in\n LV<\/jats:styled-content>\n end\u2010systolic volume at early and late follow\u2010up (\n P<\/jats:italic>\n <0.05 for both). For patients with a systemic right ventricle (n=15), there was a significant early but not late reduction in systemic right ventricular basal and longitudinal diameters. Eleven patients died, and 2 had heart transplantation unrelated to systemic ventricular morphological characteristics. Thirty\u2010five patients (65%) responded positively to\n CRT<\/jats:styled-content>\n , but only baseline\n QRS<\/jats:styled-content>\n duration was predictive of a positive response.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n CRT<\/jats:styled-content>\n results in sustained improvement in functional class, systemic\n LV<\/jats:styled-content>\n size, and function. Patients with a systemic\n LV<\/jats:styled-content>\n and prolonged\n QRS<\/jats:styled-content>\n duration, independent of\n QRS<\/jats:styled-content>\n morphological characteristics, were most likely to respond to\n CRT<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.012744","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T09:18:07Z","timestamp":1572254287000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Early and Late Effects of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease"],"prefix":"10.1161","volume":"8","author":[{"given":"Yanrong","family":"Yin","sequence":"first","affiliation":[{"name":"Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital Imperial College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adult Congenital Cardiology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Lascelles","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital Imperial College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital Imperial College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Wong","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital Imperial College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Gatzoulis","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital Imperial College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonya V.","family":"Babu\u2010Narayan","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital Imperial College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital Imperial College London London United 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