{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T10:13:50Z","timestamp":1773483230648,"version":"3.50.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In patients with mechanical heart valves, cerebral susceptibility\u2010weighted imaging (\n              <jats:styled-content style=\"fixed-case\">SWI<\/jats:styled-content>\n              ) lesions on magnetic resonance imaging, postulated to be caused by degenerative metallic abrasion, are frequently referred to as\n              <jats:italic>valve abrasion<\/jats:italic>\n              . It remains unclear whether valve implantation not requiring cardiopulmonary bypass or biological heart valves also shows those lesions.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Two blinded readers rated\n              <jats:styled-content style=\"fixed-case\">SWI<\/jats:styled-content>\n              lesions and cerebral amyloid angiopathy probability according to established criteria on brain magnetic resonance imaging pre\u2010 and postinterventionally. We assessed the association between valve type\/cardiopulmonary bypass use and\n              <jats:styled-content style=\"fixed-case\">SWI<\/jats:styled-content>\n              lesion count on the first postinterventional scan using multivariable logistic regression. On postinterventional magnetic resonance imaging, 57\/58 (98%) patients with mechanical heart valves had at least 1 and 46\/58 (79%) 3 or more\n              <jats:styled-content style=\"fixed-case\">SWI<\/jats:styled-content>\n              lesions, while 92\/97 (95%) patients with biological heart valves had at least 1 and 72\/97 (74%) 3 or more\n              <jats:styled-content style=\"fixed-case\">SWI<\/jats:styled-content>\n              lesions. On multivariate analysis, duration of cardiopulmonary bypass during implantation significantly increased the odds of having\n              <jats:styled-content style=\"fixed-case\">SWI<\/jats:styled-content>\n              lesions on the first postinterventional magnetic resonance imaging (\u03b2 per 10\u00a0minutes 0.498; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 0.116\u20130.880;\n              <jats:italic>P<\/jats:italic>\n              =0.011), whereas valve type showed no significant association (\n              <jats:italic>P<\/jats:italic>\n              =0.338). Thirty\u2010seven of 155 (23.9%) patients fulfilled the criteria of possible\/probable cerebral amyloid angiopathy.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">SWI<\/jats:styled-content>\n              lesions in patients with artificial heart valves evolve around the time point of valve implantation and the majority of patients had multiple lesions. The missing association with the valve type weakens the hypothesis of degenerative metallic abrasion and highlights cardiopulmonary bypass as the main risk factor for\n              <jats:styled-content style=\"fixed-case\">SWI<\/jats:styled-content>\n              occurrence.\n              <jats:styled-content style=\"fixed-case\">SWI<\/jats:styled-content>\n              lesions associated with cardiac procedures can mimic cerebral amyloid angiopathy. Further research needs to clarify whether those lesions are associated with intracranial hemorrhage after intravenous thrombolysis or anticoagulation.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.012814","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T09:16:07Z","timestamp":1564996567000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and Evolution of Susceptibility\u2010Weighted Imaging Lesions in Patients With Artificial Heart Valves"],"prefix":"10.1161","volume":"8","author":[{"given":"Philipe S.","family":"Breiding","sequence":"first","affiliation":[{"name":"University Institute of Diagnostic and Interventional Neuroradiology University Hospital Bern Inselspital University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana 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Interventional Neuroradiology University Hospital Bern Inselspital University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pilgrim","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Bern Inselspital University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Bern Inselspital University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Bern Inselspital University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Bern Inselspital University 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