{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:51:17Z","timestamp":1792003877838,"version":"4.4.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Lamin A\/C cardiomyopathy is a malignant and highly penetrant inheritable cardiomyopathy. Competitive sports have been associated with adverse events in these patients, but data on recreational exercise are lacking. We aimed to explore associations between exercise exposure and disease severity in patients with lamin A\/C genotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Lamin A\/C genotype positive patients answered a questionnaire on exercise habits from age 7\u00a0years until genetic diagnosis. We recorded exercise hours &gt;3 metabolic equivalents and calculated cumulative lifetime exercise. Patients were grouped in active or sedate based on lifetime exercise hours above or below median. We performed echocardiography, 12\u2010lead\n                      <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content>\n                      , Holter monitoring, and biomarkers including\n                      <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\n                      \u2010pro\n                      <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>\n                      (N\u2010terminal pro\u2010B\u2010type natriuretic peptide). We defined left ventricular ejection fraction &lt;45% as a clinically significant impairment of left ventricular function. We included 69 patients (age 42\u00b114\u00a0years, 41% probands, 46% women) with median lifetime exercise 4160 (interquartile range 1041\u20136924) hours. Active patients were more frequently probands (53% versus 29%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.04), had lower left ventricular ejection fraction (43\u00b113% versus 51\u00b111%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.006), and higher\n                      <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\n                      \u2010pro\n                      <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>\n                      (78 [interquartile range 32\u2013219] pmol\/L versus 30 [interquartile range 13\u201364] pmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      =0.03) compared with sedate, while age did not differ (45\u00b113\u00a0years versus 40\u00b116\u00a0years,\n                      <jats:italic>P<\/jats:italic>\n                      =0.16). The decrease in left ventricular ejection fraction per tertile increment in lifetime exercise was 4% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u22127% to \u22120.4%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.03), adjusted for age and sex and accounting for dependence within families. Left ventricular ejection fraction &lt;45% was observed at a younger age in active patients (log rank\n                      <jats:italic>P<\/jats:italic>\n                      =0.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Active lamin A\/C patients had worse systolic function compared with sedate which occurred at younger age. Our findings may improve exercise recommendations in patients with lamin A\/C.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.119.012937","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T05:47:27Z","timestamp":1579499247000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Exercise is Associated With Impaired Left Ventricular Systolic Function in Patients With Lamin A\/C Genotype"],"prefix":"10.1161","volume":"9","author":[{"given":"Eystein T.","family":"Skj\u00f8lsvik","sequence":"first","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Institute for Clinical Medicine University of Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina E.","family":"Hasselberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars A.","family":"Dejgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Institute for Clinical Medicine University of Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind H.","family":"Lie","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Institute for Clinical Medicine University of Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Medicine Section\u00a0of Cardiology Innlandet Hospital Trust Hamar Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f8rn","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Edvardsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Institute for Clinical Medicine University of Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina H.","family":"Haugaa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Institute for Clinical Medicine University of Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur245"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx596"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr260"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01724-2"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.078"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc052632"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.025528"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0589-1"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.01017.x"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.06.044"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.185649"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.181"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.03.002"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv110"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.008979"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.804617"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2016.05.010"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.07.015"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00023.2004"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31821ece12"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615710"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.184390"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut291"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.454"},{"key":"e_1_3_1_27_2","first-page":"CD003331","article-title":"Exercise\u2010based cardiac rehabilitation for adults with heart failure","volume":"1","author":"Long L","year":"2019","unstructured":"Long L, Mordi IR, Bridges C, Sagar VA, Davies EJ, Coats AJ, Dalal H, Rees K, Singh SJ, Taylor RS. Exercise\u2010based cardiac rehabilitation for adults with heart failure. Cochrane Database Syst Rev. 2019;1:CD003331.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.01.010"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.06.033"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2014.06.009"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199101313240504"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.010"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-1-199901050-00005"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.057"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.02.350"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90439-1"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80282-0"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.012937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:59:48Z","timestamp":1715587188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.012937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,21]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,1,21]]}},"alternative-id":["10.1161\/JAHA.119.012937"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.012937","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,21]]},"assertion":[{"value":"2019-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e012937"}}