{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:20:04Z","timestamp":1790695204244,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,9,3]]},"abstract":"\n Background<\/jats:title>\n \n Left ventricular (\n LV<\/jats:styled-content>\n ) involvement is common in arrhythmogenic right ventricular cardiomyopathy (\n ARVC<\/jats:styled-content>\n ). We aim to evaluate\n LV<\/jats:styled-content>\n involvement in\n ARVC<\/jats:styled-content>\n patients by cardiovascular magnetic resonance feature tracking.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Sixty\u2010eight patients with ARVC and 30 controls were prospectively enrolled.\n ARVC<\/jats:styled-content>\n patients were divided into 2 subgroups: the preserved LV ejection fraction (LVEF) group (\n LVEF<\/jats:styled-content>\n \u226555%, n=27) and the reduced\n LVEF<\/jats:styled-content>\n group (\n LVEF<\/jats:styled-content>\n <55%, n=41). Cardiovascular magnetic resonance with late gadolinium enhancement (\n LGE<\/jats:styled-content>\n ) and cardiovascular magnetic resonance feature tracking were performed in all subjects.\n LV<\/jats:styled-content>\n global and regional (basal, mid, apical) peak strain (\n PS<\/jats:styled-content>\n ) in radial, circumferential and longitudinal directions were assessed, respectively. Right ventricular global\n PS<\/jats:styled-content>\n in three directions were also analyzed. Compared with the controls,\n LV<\/jats:styled-content>\n global and regional\n PS<\/jats:styled-content>\n were all significantly impaired in the reduced\n LVEF<\/jats:styled-content>\n group (all\n P<\/jats:italic>\n <0.05). However, only\n LV<\/jats:styled-content>\n global longitudinal\n PS<\/jats:styled-content>\n as well as mid and apical longitudinal\n PS<\/jats:styled-content>\n were impaired in the preserved\n LVEF<\/jats:styled-content>\n group (all\n P<\/jats:italic>\n <0.05), and all these parameters were significantly associated with right ventricular global radial\n PS<\/jats:styled-content>\n (\n r<\/jats:italic>\n =\u22120.47, \u22120.47, and \u22120.49, respectively, all\n P<\/jats:italic>\n <0.001). The reduced\n LVEF<\/jats:styled-content>\n group showed significantly higher prevalence of\n LGE<\/jats:styled-content>\n (95.10% versus 63.00%,\n P<\/jats:italic>\n =0.002) than the preserved\n LVEF<\/jats:styled-content>\n group. Moreover,\n LV<\/jats:styled-content>\n radial\n PS<\/jats:styled-content>\n was significantly reduced in\n LV<\/jats:styled-content>\n segments with\n LGE<\/jats:styled-content>\n (33.15\u00b120.42%, n=46) than those without\n LGE<\/jats:styled-content>\n (41.25\u00b115.98%, n=386) in the preserved\n LVEF<\/jats:styled-content>\n group (\n P<\/jats:italic>\n =0.016).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients with\n ARVC<\/jats:styled-content>\n , cardiovascular magnetic resonance feature tracking could detect early\n LV<\/jats:styled-content>\n dysfunction, which was associated with\n LV<\/jats:styled-content>\n myocardial\n LGE<\/jats:styled-content>\n and right ventricular dysfunction.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.012989","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T09:14:12Z","timestamp":1566551652000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Early Left Ventricular Involvement Detected by Cardiovascular Magnetic Resonance Feature Tracking in Arrhythmogenic Right Ventricular Cardiomyopathy: The Effects of Left Ventricular Late Gadolinium Enhancement and Right Ventricular Dysfunction"],"prefix":"10.1161","volume":"8","author":[{"given":"Xiuyu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaibin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Function Test Center State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Han","sequence":"additional","affiliation":[{"name":"Circle Cardiovascular Imaging Inc. Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.05.065"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12222"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr040"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.041"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.11.020"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004077"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.970434"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu181"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.09.194"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.01.013"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.840827"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2007.903693"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.10.009"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-016-0269-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0380-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3137-6"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.11.006"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev227"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-017-1199-7"},{"key":"e_1_3_2_21_2","first-page":"761","article-title":"Reference ranges for three\u2010dimensional feature tracking cardiac magnetic resonance: comparison with two\u2010dimensional methodology and relevance of age and gender","volume":"34","author":"Liu B","year":"2018","unstructured":"Liu B, Dardeer AM, Moody WE, Hayer MK, Baig S, Price AM, Leyva F, Edwards NC, Steeds RP. Reference ranges for three\u2010dimensional feature tracking cardiac magnetic resonance: comparison with two\u2010dimensional methodology and relevance of age and gender. 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