{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:59Z","timestamp":1787018099243,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,8,20]]},"abstract":"\n Background<\/jats:title>\n \n Cardiovascular disease (\n CVD<\/jats:styled-content>\n ) and fatigue commonly co\u2010occur in older adults, yet the subjective nature of fatigue and its situational dependence leave the true magnitude of this association undefined.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Six\u2010hundred and twenty\u2010five participants with no history of\n CVD<\/jats:styled-content>\n (aged 68.1+12.0\u00a0years), from the Baltimore Longitudinal Study of Aging who underwent \u22652 clinic visits between 2007 and 2015 were classified according to sex\u2010specific predicted 10\u2010year\n CVD<\/jats:styled-content>\n risk scores using the Framingham\n CVD<\/jats:styled-content>\n risk score (Framingham) and the Pooled Cohort Equation at baseline. Perceived fatigability was assessed using the Borg rating of perceived exertion scale after a 5\u2010minute treadmill walk (0.67\u00a0m\/s, 0% grade). Linear models were used to assess the association between baseline\n CVD<\/jats:styled-content>\n risk and perceived fatigability an average of 4.5\u00a0years later, adjusted for demographics, behaviors, and medical history. In final models, a 5% higher baseline Pooled Cohort Equation score was associated with greater perceived fatigability at follow\u2010up (\u03b2=0.13 rating of perceived exertion,\n P<\/jats:italic>\n =0.008). Stratified analyses suggested this association was stronger among those aged \u226470\u00a0years and those with obesity. Of the individual\n CVD<\/jats:styled-content>\n risk score components, older age was most strongly associated with perceived fatigability (\u03b2=0.48,\n P<\/jats:italic>\n <0.001), followed by women (\u03b2=0.11,\n P<\/jats:italic>\n =0.002), and treated hypertension (\u03b2=0.11,\n P<\/jats:italic>\n =0.003). There was no association with the Framingham risk score.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Perceived fatigability was higher among participants with greater\n CVD<\/jats:styled-content>\n risk measured using the Pooled Cohort Equation risk score. The strong associations with hypertension and obesity suggest prevention and promotion of cardiovascular health may also lower perceived fatigability, particularly among those aged \u226470\u00a0years or living with obesity.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.013049","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T05:00:20Z","timestamp":1565758820000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Association Between Cardiovascular Risk and Perceived Fatigability in Mid\u2010to\u2010Late Life"],"prefix":"10.1161","volume":"8","author":[{"given":"Yujia","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Martinez\u2010Amezcua","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD"},{"name":"Center on Aging and Health Johns Hopkins University Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal A.","family":"Wanigatunga","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD"},{"name":"Center on Aging and Health Johns Hopkins University Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek K.","family":"Urbanek","sequence":"additional","affiliation":[{"name":"Center on Aging and Health Johns Hopkins University Baltimore MD"},{"name":"Division of Geriatrics & Gerontology Johns Hopkins School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor M.","family":"Simonsick","sequence":"additional","affiliation":[{"name":"Intramural Research Program National Institute on Aging Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Intramural Research Program National Institute on Aging Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Schrack","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD"},{"name":"Center on Aging and Health Johns Hopkins University Baltimore MD"},{"name":"Intramural Research Program National Institute on Aging Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","unstructured":"World Health Organization . Noncommunicable diseases country profiles 2018. 2018."},{"key":"e_1_3_1_3_2","unstructured":"World Health Organization . Global status report on noncommunicable disease 2010. 2011."},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000152"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.84.3.351"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/NNR.0000000000000019"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324782"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12638"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2010.03.022"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.03.037"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.12.005"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-017-0979-9"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/21.4.575"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437741.48606.98"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1249\/00003677-199700250-00017"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/28.6.1379"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.320"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016669861"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0087-0"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22500"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6748.362"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn146"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.351"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.3.204"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4623-y"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12685"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03088.x"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly120"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.07802"},{"key":"e_1_3_1_31_2","first-page":"158","article-title":"Inflammation, immunity, and hypertension","volume":"49","author":"Agita A","year":"2017","unstructured":"Agita A, Alsagaff MT. Inflammation, immunity, and hypertension. Acta Med Indones. 2017;49:158\u2013165.","journal-title":"Acta Med Indones"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-016-0628-7"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu071"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx181"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.013049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:39:22Z","timestamp":1715585962000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.013049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,20]]},"references-count":33,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,8,20]]}},"alternative-id":["10.1161\/JAHA.119.013049"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.013049","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,20]]},"assertion":[{"value":"2019-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e013049"}}