{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:59:09Z","timestamp":1785549549515,"version":"3.56.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,11,5]]},"abstract":"\n Background<\/jats:title>\n \n The diagnosis of ischemic cerebellar stroke is challenging because of nonspecific symptoms and very limited accuracy of commonly applied computed tomography (\n CT<\/jats:styled-content>\n ) imaging. Advances in\n CT<\/jats:styled-content>\n perfusion imaging provide increasing value in the detection of posterior circulation stroke, but the prognostic value remains unclear. We aimed to identify imaging parameters that predict morphologic outcome in cerebellar stroke patients using advanced\n CT<\/jats:styled-content>\n including whole\u2010brain\n CT<\/jats:styled-content>\n perfusion (\n WB<\/jats:styled-content>\n \u2010\n CTP<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We selected all subjects with cerebellar\n WB<\/jats:styled-content>\n \u2010\n CTP<\/jats:styled-content>\n perfusion deficits and follow\u2010up\u2010confirmed cerebellar infarction from a consecutive cohort with suspected stroke who underwent\n WB<\/jats:styled-content>\n \u2010\n CTP<\/jats:styled-content>\n . Posterior\u2010circulation\u2010Acute\u2010Stroke\u2010Prognosis\u2010Early\u2010\n CT<\/jats:styled-content>\n \u2010Score (pc\u2010\n ASPECTS<\/jats:styled-content>\n ) was determined on noncontrast\n CT<\/jats:styled-content>\n ,\n CT<\/jats:styled-content>\n angiography source images, and on parametric\n WB<\/jats:styled-content>\n \u2010\n CTP<\/jats:styled-content>\n maps. Cerebellar perfusion deficit volumes on all maps and the final infarction volume on follow\u2010up imaging were quantified. Uni\u2010 and multivariate regression analyses were performed. Sixty patients fulfilled the inclusion criteria. pc\u2010\n ASPECTS<\/jats:styled-content>\n on\n CT<\/jats:styled-content>\n angiography source images (\u00df, \u22129.239; 95%\n CI<\/jats:styled-content>\n , \u221214.220 to \u22124.259;\n P<\/jats:italic>\n <0.001) and cerebral blood flow deficit volume (\u00df, 0.886; 95%\n CI<\/jats:styled-content>\n , 0.684 to 1.089;\n P<\/jats:italic>\n <0.001) were significantly associated with final infarction volume in univariate linear regression analysis. The association of cerebral blood flow deficit volume (\u00df, 0.830; 95%\n CI<\/jats:styled-content>\n , 0.605\u20131.055;\n P<\/jats:italic>\n <0.001) was confirmed in a multivariate linear regression model adjusted for age, sex, pc\u2010\n ASPECTS<\/jats:styled-content>\n on noncontrast\n CT<\/jats:styled-content>\n , and\n CT<\/jats:styled-content>\n angiography source images and the National Institutes of Health Stroke Scale score on admission. No other clinical or imaging parameters were associated with cerebellar stroke final infarction volume (\n P<\/jats:italic>\n >0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In contrast to noncontrast\n CT<\/jats:styled-content>\n and CT angiography,\n WB<\/jats:styled-content>\n \u2010\n CTP<\/jats:styled-content>\n imaging contains prognostic information for morphologic outcome in patients with acute cerebellar stroke.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.013069","type":"journal-article","created":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T09:08:05Z","timestamp":1571476085000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Incremental Value of Computed Tomography Perfusion for Final Infarct Prediction in Acute Ischemic Cerebellar Stroke"],"prefix":"10.1161","volume":"8","author":[{"given":"Matthias P.","family":"Fabritius","sequence":"first","affiliation":[{"name":"Department ot Radiology University Hospital, LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Reidler","sequence":"additional","affiliation":[{"name":"Department ot Radiology University Hospital, LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias F.","family":"Froelich","sequence":"additional","affiliation":[{"name":"Department ot Radiology University Hospital, LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas T.","family":"Rotkopf","sequence":"additional","affiliation":[{"name":"Department ot Radiology University Hospital, LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Liebig","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University Hospital LMU Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Kellert","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital LMU Munich Germany"},{"name":"Department of Neurology University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Feil","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital LMU Munich Germany"},{"name":"German Center for Vertigo and Balance Disorders University Hospital LMU Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Tiedt","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research University Hospital LMU Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp M.","family":"Kazmierczak","sequence":"additional","affiliation":[{"name":"Department ot Radiology University Hospital, LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kolja M.","family":"Thierfelder","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology Pediatric Radiology and Neuroradiology University Medical Center Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Puhr\u2010Westerheide","sequence":"additional","affiliation":[{"name":"Department ot Radiology University Hospital, LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang G.","family":"Kunz","sequence":"additional","affiliation":[{"name":"Department ot Radiology University Hospital, LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70216-3"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/2013.2.FOCUS12363"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181e1956f"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008718"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-016-1743-5"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443618"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20638"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.619734"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001068"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4637"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-015-1636-z"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018237"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004188"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16686594"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4613-y"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.511162"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1179-0"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.7.864"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.604"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.671594"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000481459"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017744465"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.532838"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.87"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.8496"}],"container-title":["Journal 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