{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:23:06Z","timestamp":1793024586687,"version":"4.5.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,10]]},"abstract":"\n Background<\/jats:title>\n Identifying pregnancy\u2010associated risk factors before the development of major cardiovascular disease events could provide opportunities for prevention. The objective of this study was to determine the association between outcomes in first pregnancies and subsequent cardiovascular health.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The Nulliparous Pregnancy Outcomes Study Monitoring Mothers\u2010to\u2010be Heart Health Study is a prospective observational cohort that followed 4484 women 2 to 7\u00a0years (mean 3.2\u00a0years) after their first pregnancy. Adverse pregnancy outcomes (defined as hypertensive disorders of pregnancy, small\u2010for\u2010gestational\u2010age birth, preterm birth, and stillbirth) were identified prospectively in 1017 of the women (22.7%) during this pregnancy. The primary outcome was incident hypertension (\n HTN<\/jats:styled-content>\n ). Women without adverse pregnancy outcomes served as controls. Risk ratios (\n RR<\/jats:styled-content>\n ) and 95%\n CI<\/jats:styled-content>\n s were adjusted for age, smoking, body mass index, insurance type, and race\/ethnicity at enrollment during pregnancy. The overall incidence of\n HTN<\/jats:styled-content>\n was 5.4% (95%\n CI<\/jats:styled-content>\n 4.7% to 6.1%). Women with adverse pregnancy outcomes had higher adjusted risk of\n HTN<\/jats:styled-content>\n at follow\u2010up compared with controls (\n RR<\/jats:styled-content>\n 2.4, 95%\n CI<\/jats:styled-content>\n 1.8\u20103.1). The association held for individual adverse pregnancy outcomes: any hypertensive disorders of pregnancy (\n RR<\/jats:styled-content>\n 2.7, 95%\n CI<\/jats:styled-content>\n 2.0\u20103.6), preeclampsia (\n RR<\/jats:styled-content>\n 2.8, 95%\n CI<\/jats:styled-content>\n 2.0\u20104.0), and preterm birth (\n RR<\/jats:styled-content>\n 2.7, 95%\n CI<\/jats:styled-content>\n 1.9\u20103.8). Women who had an indicated preterm birth and hypertensive disorders of pregnancy had the highest risk of\n HTN<\/jats:styled-content>\n (\n RR<\/jats:styled-content>\n 4.3, 95%\n CI<\/jats:styled-content>\n 2.7\u20106.7).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Several pregnancy complications in the first pregnancy are associated with development of\n HTN<\/jats:styled-content>\n 2 to 7\u00a0years later. Preventive care for women should include a detailed pregnancy history to aid in counseling about\n HTN<\/jats:styled-content>\n risk.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n Unique identifier:\n NCT<\/jats:styled-content>\n 02231398.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.013092","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T10:37:01Z","timestamp":1569839821000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":118,"title":["Association of Adverse Pregnancy Outcomes With Hypertension 2 to 7\u00a0Years Postpartum"],"prefix":"10.1161","volume":"8","author":[{"given":"David M.","family":"Haas","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine","place":["Indianapolis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corette B.","family":"Parker","sequence":"additional","affiliation":[{"name":"RTI International","place":["Research Triangle Park"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"Marsh","sequence":"additional","affiliation":[{"name":"RTI International","place":["Research Triangle Park"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Grobman","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine","place":["Chicago"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah B.","family":"Ehrenthal","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health","place":["Madison"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Greenland","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine","place":["Chicago"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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