{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:50:21Z","timestamp":1783396221072,"version":"3.54.6"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Recurrent hospitalization is prevalent in women with signs and symptoms of ischemia and no obstructive coronary artery disease. We hypothesized that rates of angina hospitalization might have changed over time, given advances in diagnostic and therapeutic approaches.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We evaluated 551 women enrolled in the WISE (Women's Ischemia Syndrome Evaluation) study with no obstructive coronary artery disease (CAD) for a follow\u2010up period of 9.1\u00a0years. We analyzed angina hospitalization rates using the Kaplan\u2010Meier method. Univariate analysis and multivariable Cox proportional hazard models were developed for prediction of angina hospitalization in women with signs and symptoms of angina and no CAD. A total of 223 women had nonobstructive CAD (&gt;20\u201350% &lt;stenosis) and 328 had no CAD (&lt;20% stenosis). Among women with either no or nonobstructive CAD, the mean age was 56\u00b111\u00a0years, 56% had hypertension, 46% dyslipidemia, 51% were smokers, and 10% had prior myocardial infarction. The rates of angina hospitalization for a maximum of 9.1\u00a0years showed near\u2010linear increases in both groups (\n              <jats:italic>P<\/jats:italic>\n              =0.03). Hypertension, dyslipidemia, nonobstructive CAD, use of nitrates, statins, and angiotensin\u2010converting enzyme inhibitors were univariate predictors of angina hospitalization. Adjusted multivariate hazard ratios for angina hospitalization were significant for use of nitrates 2.58 (1.80\u20133.69,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), statins 1.80 (1.20\u20132.70,\n              <jats:italic>P<\/jats:italic>\n              =0.004), and angiotensin\u2010converting enzyme inhibitors\/angiotensin II receptor blockers 1.81 (1.22\u20132.68,\n              <jats:italic>P<\/jats:italic>\n              =0.003).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Angina hospitalization rates continued at a relatively constant rate in all women with no obstructive CAD despite medical advances. Clinical trials aimed at reducing angina hospitalization rates and identifying the pathophysiological mechanisms contributing to angina symptoms in women with no CAD and women with no obstructive CAD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013168","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T10:00:34Z","timestamp":1581933634000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Angina Hospitalization Rates in Women With Signs and Symptoms of Ischemia But no Obstructive Coronary Artery Disease: A Report from the WISE (Women's Ischemia Syndrome Evaluation) Study"],"prefix":"10.1161","volume":"9","author":[{"given":"Haider","family":"Aldiwani","sequence":"first","affiliation":[{"name":"Barbra Streisand Women's Heart Center Cedars\u2010Sinai Heart Smidt Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melody","family":"Zaya","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Cedars\u2010Sinai Heart Smidt Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nissi","family":"Suppogu","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Cedars\u2010Sinai Heart Smidt Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odayme","family":"Quesada","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Cedars\u2010Sinai Heart Smidt Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Delia","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja K.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Emory University Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrisandra","family":"Shufelt","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Cedars\u2010Sinai Heart Smidt Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Petersen","sequence":"additional","affiliation":[{"name":"University of Florida Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Azarbal","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Cedars\u2010Sinai Heart Smidt Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Samuels","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Cedars\u2010Sinai Heart Smidt Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. David","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of Florida Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslee J.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Emory University Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saibal","family":"Kar","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Cedars\u2010Sinai Heart Smidt Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Handberg","sequence":"additional","affiliation":[{"name":"University of Florida Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl F.","family":"Kelsey","sequence":"additional","affiliation":[{"name":"University of Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[{"name":"University of Florida Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Noel","family":"Bairey Merz","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Cedars\u2010Sinai Heart Smidt Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024534"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.08.068"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008868"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093170"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.072"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.726562"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.04.002"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.116.003863"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00082-0"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.50"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.27.6.1491"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/CVM-2-2-075"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.981613"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.013168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:27:51Z","timestamp":1715599671000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.013168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,2,18]]}},"alternative-id":["10.1161\/JAHA.119.013168"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.013168","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"2019-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e013168"}}