{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:35:00Z","timestamp":1773009300802,"version":"3.50.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,11,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">An increased risk of acute ischemic stroke is recognized among patients with cancer. However, the mechanism behind cancer\u2010related stroke is unclear. In this study, we determined the presence of associated venous thromboembolism and arterial thromboembolism and their clinical impact on patients with cancer\u2010related stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with embolic stroke of undetermined source with or without cancer were evaluated for venous thromboembolism (deep vein thrombosis [\n              <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>\n              ] and\/or pulmonary embolism) and arterial thromboembolism by using Doppler sonography to determine the presence of lower\u2010extremity\n              <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>\n              and the microembolic signal of the symptomatic cerebral circulation, respectively. Infarct volume was determined by diffusion\u2010weighted magnetic resonance imaging. The multivariable linear regression and Cox proportional hazard analysis were used to investigate the effect of\n              <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>\n              and microembolic signal on infarct volume and 1\u2010year survival, respectively. Of 142 screened patients, 118 were included (37 with, 81 without cancer). Those with cancer had a higher prevalence of\n              <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>\n              or microembolic signal than did the noncancer group (62.2% versus 19.8%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Among patients with cancer\u2010related stroke,\n              <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>\n              was associated with a greater infarct volume in magnetic resonance imaging (beta, 13.14; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.62\u201324.66;\n              <jats:italic>P<\/jats:italic>\n              =0.028). Presence of\n              <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>\n              (hazard ratio, 16.79; 95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              2.05\u2013137.75;\n              <jats:italic>P<\/jats:italic>\n              =0.009) and microembolic signal (hazard ratio, 8.16; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.36\u201348.85;\n              <jats:italic>P<\/jats:italic>\n              =0.022) were independent predictors of poor 1\u2010year survival.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with cancer\u2010associated embolic stroke of undetermined source have an elevated risk of associated venous thromboembolism and arterial thromboembolism, both of which have a significant negative impact on 1\u2010year survival. The results of this study may enhance our understanding of cancer\u2010associated stroke and improve risk stratification of patients with this disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/.Unique\">https:\/\/www.clinicaltrials.gov\/.Unique<\/jats:ext-link>\n              identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              02212496\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013215","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T09:04:08Z","timestamp":1571821448000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence and Impact of Venous and Arterial Thromboembolism in Patients With Embolic Stroke of Undetermined Source With or Without Active Cancer"],"prefix":"10.1161","volume":"8","author":[{"given":"Jongmok","family":"Ha","sequence":"first","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2010yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Electronic Electrical and Computer Engineering Sungkyunkwan University Suwon Republic of Korea"},{"name":"Center for Neuroscience Imaging Research Institute for Basic Science (IBS) Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunjin","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Imaging Research Institute for Basic Science (IBS) Suwon Republic of Korea"},{"name":"School of Electronic and Electrical Engineering Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soohyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Won","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo\u2010Keun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyeong\u2010Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of 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