{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:39:10Z","timestamp":1758962350690,"version":"3.41.2"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Circulating levels of sFLT\u20101 (soluble fms\u2010like tyrosine kinase 1), the extracellular domain of vascular endothelial growth factor (VEGF) receptor 1, and its ratio to levels of placental growth factor are markers of the occurrence and severity of preeclampsia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              C57BL\/6 pregnant mice on embryonic day 14.5 (E14.5), male, and non\u2010pregnant female mice were exposed to air or to Br\n              <jats:sub>2<\/jats:sub>\n              at 600\u00a0ppm for 30\u00a0minutes and were treated with vehicle or with VEGF\u2010121 (100\u00a0\u03bcg\/kg, subcutaneously) daily, starting 48\u00a0hours post\u2010exposure. Plasma, bronchoalveolar lavage fluid, lungs, fetuses, and placentas were collected 120\u00a0hours post\u2010exposure. In Br\n              <jats:sub>2<\/jats:sub>\n              \u2010exposed pregnant mice, there was a time\u2010dependent and significant increase in plasma levels of sFLT\u20101 which correlated with increases in mouse lung wet\/dry weights and bronchoalveolar lavage fluid protein content. Supplementation of exogenous VEGF\u2010121 improved survival and weight gain, reduced lung wet\/dry weights, decreased bronchoalveolar lavage fluid protein levels, enhanced placental development, and improved fetal growth in pregnant mice exposed to Br\n              <jats:sub>2<\/jats:sub>\n              . Exogenous VEGF\u2010121 administration had no effect in non\u2010pregnant mice.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">These results implicate inhibition of VEGF signaling driven by sFLT\u20101 overexpression as a mechanism of pregnancy\u2010specific injury leading to lung edema, maternal mortality, and fetal growth restriction after bromine gas exposure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013238","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T11:12:30Z","timestamp":1580728350000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Vascular Endothelial Growth Factor\u2010121 Administration Mitigates Halogen Inhalation\u2010Induced Pulmonary Injury and Fetal Growth Restriction in Pregnant 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