{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:38:35Z","timestamp":1791923915341,"version":"4.3.4"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,11,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Primary aldosteronism is the most common cause of secondary hypertension and is associated with left ventricular hypertrophy. However, whether aldosterone\u00a0excess is responsible for left ventricular (LV) diastolic dysfunction is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We prospectively enrolled 129 patients with aldosterone\u2010producing adenoma and 120 patients with essential hypertension, and analyzed their clinical, biochemical, and echocardiographic data, including tissue Doppler images. The patients with aldosterone\u2010producing adenoma were reevaluated 1\u00a0year after adrenalectomy. After propensity score matching, there were 105 patients in each group. The patients with aldosterone\u2010producing adenoma had worse diastolic function than the patients with essential hypertension, as reflected by lower e\u2032 (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and higher E\/e\u2032 (\n              <jats:italic>P<\/jats:italic>\n              =0.003). Multivariate analysis showed that LV diastolic function was significantly correlated with age (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), sex (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), body mass index (\n              <jats:italic>P<\/jats:italic>\n              =0.002), systolic blood pressure (\n              <jats:italic>P<\/jats:italic>\n              =0.004), creatinine (\n              <jats:italic>P<\/jats:italic>\n              =0.008), and log\u2010transformed aldosterone\u2010renin ratio (\n              <jats:italic>P<\/jats:italic>\n              =0.003). After adrenalectomy, the patients with aldosterone\u2010producing adenoma had significant improvements in LV diastolic function as reflected by an increase in e\u2032 (\n              <jats:italic>P<\/jats:italic>\n              =0.003) and decrease in E\/e\u2032 (\n              <jats:italic>P<\/jats:italic>\n              =0.002). The change in E\/e\u2032 was independently correlated with baseline E\/e\u2032 (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and change in LV mass index (\n              <jats:italic>P<\/jats:italic>\n              =0.006).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The patients with primary aldosteronism had worse LV diastolic function than the patients with essential hypertension after propensity score matching, and this could be reversed after adrenalectomy, suggesting that aldosterone excess may induce LV diastolic dysfunction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013263","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T10:00:27Z","timestamp":1573639227000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Left Ventricular Dysfunction in Patients With Primary Aldosteronism: A Propensity Score\u2013Matching Follow\u2010Up Study With Tissue Doppler Imaging"],"prefix":"10.1161","volume":"8","author":[{"given":"Yi\u2010Yao","family":"Chang","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Cardiology Division of Cardiovascular Medical Center Far Eastern Memorial Hospital New Taipei City Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Center of General Education Chihlee University of Technology New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che\u2010Wei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Hsin\u2010Chu Branch Hsin\u2010Chu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Hsuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Way","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Yun\u2010Lin Branch Yun\u2010Lin Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Ting","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Yun\u2010Lin Branch Yun\u2010Lin Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lung\u2010Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ru","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u2010Cent","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan\u2010Dun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Sheng","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Internal 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