{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:43:43Z","timestamp":1794271423284,"version":"4.9.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,9,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Transcatheter mitral valve replacement (\n              <jats:styled-content style=\"fixed-case\">TMVR<\/jats:styled-content>\n              ) has emerged as an alternative therapeutic option for the treatment of severe mitral regurgitation in patients with prohibitive or high surgical risk. The aim of this systematic review is to evaluate the clinical procedural characteristics and outcomes associated with the early\n              <jats:styled-content style=\"fixed-case\">TMVR<\/jats:styled-content>\n              experience.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Published studies and international conference presentations reporting data on\n              <jats:styled-content style=\"fixed-case\">TMVR<\/jats:styled-content>\n              systems were identified. Only records including clinical characteristics, procedural results, and 30\u2010day and midterm outcomes were analyzed. A total of 16 publications describing 308 patients were analyzed. Most patients (65.9%) were men, with a mean age of 75 years (range: 69\u201381 years) and Society for Thoracic Surgery Predicted Risk of Mortality score of 7.7% (range: 6.1\u20138.6%). The etiology of mitral regurgitation was predominantly secondary or mixed (87.1%), and 81.5% of the patients were in New York Heart Association class\n              <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n              or\n              <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n              . A transapical approach was used in 81.5% of patients, and overall technical success was high (91.7%). Postprocedural mean transmitral gradient was 3.5 mm\u00a0Hg (range: 3\u20135.5 mm\u00a0Hg), and only 4 cases (1.5%) presented residual moderate to severe mitral regurgitation. Procedural and all\u2010cause 30\u2010day mortality were 4.6% and 13.6%, respectively. Left ventricular outflow obstruction and conversion to open heart surgery were reported in 0.3% and 4% of patients, respectively. All\u2010cause and cardiovascular\u2010related mortality rates were 27.6% and 23.3%, respectively, after a mean follow\u2010up of 10 (range: 3 to 24) months.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">TMVR<\/jats:styled-content>\n              was a feasible, less invasive alternative for treating severe mitral regurgitation in patients with high or prohibitive surgical risk.\n              <jats:styled-content style=\"fixed-case\">TMVR<\/jats:styled-content>\n              was associated with a high rate of successful valve implantation and excellent hemodynamic results. However, periprocedural complications and all\u2010cause mortality were relatively high.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013332","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T09:16:06Z","timestamp":1566551766000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":84,"title":["Early Experience With Transcatheter Mitral Valve Replacement: A Systematic Review"],"prefix":"10.1161","volume":"8","author":[{"given":"David","family":"del Val","sequence":"first","affiliation":[{"name":"Quebec Heart &amp; Lung Institute Laval University Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo Nunes","family":"Ferreira\u2010Neto","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute Laval University Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Wintzer\u2010Wehekind","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute Laval University Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Dagenais","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute Laval University Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Michel","family":"Paradis","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute Laval University Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Bernier","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute Laval University Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute Laval University Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Beaudoin","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute Laval University Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afonso B.","family":"Freitas\u2010Ferraz","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute Laval University Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Rod\u00e9s\u2010Cabau","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute Laval University Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-307020"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm001"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00558-4"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311412"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.02.045"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.3656"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.10.056"},{"key":"e_1_3_1_10_2","unstructured":"Williams M. 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