{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:59Z","timestamp":1787018099866,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,9,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      It is unclear whether high\u2010sensitivity troponin T (hs\u2010TnT) is associated with subclinical cardiac changes in chronic kidney disease (\n                      <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                      ). We evaluated the relationship between hs\u2010TnT and left ventricular structure and function in a\n                      <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                      population, according to estimated glomerular filtration rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We analyzed 2017 patients with\n                      <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                      stages 1 to 5 (predialysis) in the\n                      <jats:styled-content style=\"fixed-case\">KNOW<\/jats:styled-content>\n                      \u2010CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) cohort. The predictor was hs\u2010TnT level measured at baseline, and the outcomes were left ventricular hypertrophy (\n                      <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>\n                      ) and systolic and diastolic dysfunction shown by echocardiography at baseline and after 4\u00a0years. Participants were categorized into quartiles according to hs\u2010TnT levels. The associations between quartiles of hs\u2010TnT and outcomes were assessed using multivariable logistic regression analysis with confounders including demographics, medical history, and laboratory findings. A receiver operating characteristic curve was used to assess the diagnostic power of hs\u2010TnT for the outcomes as a continuous variable. For subgroup analysis, patients were stratified based on an estimated glomerular filtration rate of 60\u00a0mL\/min per 1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      . Elevated hs\u2010TnT was associated with\n                      <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>\n                      and diastolic dysfunction at baseline in an adjusted model but was not associated with systolic dysfunction. These associations remained significant for both estimated glomerular filtration rate subgroups. Receiver operating characteristic curve analysis showed that hs\u2010TnT as a continuous variable exhibited fair significance for detection of\n                      <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>\n                      (area under the curve: 0.689) and diastolic dysfunction (area under the curve: 0.744). Multivariable analysis showed that higher hs\u2010TnT levels at baseline were related to development of\n                      <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>\n                      but not diastolic dysfunction (n=864).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In\n                      <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                      patients, hs\u2010TnT is strongly associated with alterations of left ventricular structure and diastolic dysfunction for both estimated glomerular filtration rate strata. Baseline hs\u2010TnT levels are predictive of new\n                      <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>\n                      on follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.119.013357","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T05:04:06Z","timestamp":1568351046000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Association Between High\u2010Sensitivity Cardiac Troponin T and Echocardiographic Parameters in Chronic Kidney Disease: Results From the KNOW\u2010CKD Cohort Study"],"prefix":"10.1161","volume":"8","author":[{"given":"Eunjeong","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayoun","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Research Collaborating Center Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joongyub","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Prevention and Management Inha University Hospital Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Beck","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine School of Medicine Kangbuk Samsung Hospital Sungkyunkwan University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Wan","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Ah","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Nowon Eulji Medical Center Eulji University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Wan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curie","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kook\u2010Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283424188"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.19.2346"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.026"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1768"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1708"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.875"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.185322"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-015-0581-x"},{"key":"e_1_3_2_10_2","first-page":"212","article-title":"Original article: brain natriuretic peptide (BNP), N\u2010terminal pro\u2010BNP (NT\u2010proBNP) and cardiac troponin T (cTnT) as markers of cardiac diseases in stable hemodialysis patients","volume":"26","author":"Hyunjeong B","year":"2007","unstructured":"Hyunjeong B, Jung Ah K, So\u2010Yeon C, Yeon\u2010Sil D, Eun\u2010Hee J, Jung In K, Jung Ho D, Sung Chul C, Jung Eun L, Wooseong H, Dae Joong K, Ha\u2010Young O, Seung W. Original article: brain natriuretic peptide (BNP), N\u2010terminal pro\u2010BNP (NT\u2010proBNP) and cardiac troponin T (cTnT) as markers of cardiac diseases in stable hemodialysis patients. Kidney Res Clin Pract. 2007;26:212\u2013219. Available at: http:\/\/www.krcp-ksn.org\/journal\/view.html?uid=2948&vmd=Full.","journal-title":"Kidney Res Clin Pract"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-80"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.2.221"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00540-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04860709"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.123877"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.11.034"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.33914"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014010108"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.05.004"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.2017.36.4.358"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000109483.45211.8F"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/chf.12030"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.5.759"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00219.x"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2006.00135.x"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2004.07.005"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.3.353"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.069666"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.5301\/JN.2010.2030"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.013357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:47:22Z","timestamp":1715586442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.013357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,17]]},"references-count":33,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2019,9,17]]}},"alternative-id":["10.1161\/JAHA.119.013357"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.013357","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,17]]},"assertion":[{"value":"2019-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e013357"}}