{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:33:17Z","timestamp":1787682797359,"version":"build-2784847793"},"reference-count":68,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,9,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiovascular involvement in systemic sclerosis (\n              <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n              c) comprises a wide range of manifestations with prevalence and incidence that remain uncertain.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In the Danish administrative registries between 1995 and 2015, all patients aged \u226518\u00a0years with a first diagnosis of\n              <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n              c were matched by age and sex with controls (1:5) from the general population. Prevalence of cardiovascular diseases at the time of the\n              <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n              c diagnosis and incidence during follow\u2010up were assessed by in\u2010 and outpatient discharge diagnoses. Conditional logistic and Cox proportional hazards regression models were used respectively to calculate odds ratios for prevalent cardiovascular diseases and hazard ratios (\n              <jats:styled-content style=\"fixed-case\">HRs<\/jats:styled-content>\n              ) for incident diseases associated with\n              <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n              c. Patients with\n              <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n              c (n=2778; 76% women; mean\u00b1SD age: 55\u00b115\u00a0years) had more established cardiovascular risk factors than their respective controls at baseline, including greater prevalence of hypertension (31.2% versus 21.0%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and treated dyslipidemia (9.8% versus 8.5%,\n              <jats:italic>P<\/jats:italic>\n              =0.02).\n              <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n              c was associated with an increased relative risk of developing most cardiovascular diseases, including myocardial infarction (HR: 2.08; 95% CI, 1.65\u20132.64), peripheral vascular disease (HR: 5.73; 95% CI, 4.63\u20137.09), pulmonary hypertension (HR: 21.18; 95% CI, 14.73\u201330.45), mitral regurgitation (HR: 4.60; 95% CI, 3.12\u20136.79), aortic regurgitation (HR: 3.78; 95% CI, 2.55\u20135.58), aortic stenosis (HR: 2.99; 95% CI, 2.25\u20133.97), pericarditis (HR: 8.78; 95% CI, 4.84\u201315.93), heart failure (HR: 2.86; 95% CI, 2.43\u20133.37), atrial fibrillation (HR: 1.75; 95% CI, 1.51\u20132.04), and venous thromboembolism (HR: 2.10; 95% CI, 1.65\u20132.67). Additional adjustment for medications and comorbidities yielded results similar to the main analyses.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this nationwide study,\n              <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n              c was associated with greater risks of distinct cardiovascular diseases for patients than for matched controls, suggesting a significant disease\u2010related adverse impact across the vascular bed and specific cardiac structures.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013405","type":"journal-article","created":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T09:02:09Z","timestamp":1566637329000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":98,"title":["Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study"],"prefix":"10.1161","volume":"8","author":[{"given":"Sheraz A.","family":"Butt","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology Amager Hvidovre Hospital Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen L.","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Amager Hvidovre Hospital Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Sam","sequence":"additional","affiliation":[{"name":"Whitaker Cardiovascular Institute and Department of Cardiology Boston University School of Medicine Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar H.","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev and Gentofte Hospital Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Copenhagen Lupus and Vasculitis Clinic Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114264"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-016-3530-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0505-5"},{"key":"e_1_3_2_5_2","first-page":"8","article-title":"Cardiovascular disease in systemic sclerosis","volume":"3","author":"Cannarile F","year":"2015","unstructured":"Cannarile F, Valentini V, Mirabelli G, Alunno A, Terenzi R, Luccioli F, Gerli R, Bartoloni E. Cardiovascular disease in systemic sclerosis. Ann Transl Med. 2015;3:8.","journal-title":"Ann Transl Med"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2013.10.007"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2842"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.1.39"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1038456"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23463"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.057760"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281110"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel315"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-11-83"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012832"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012817"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d124"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-018-0043-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115111"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0248-z"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210645"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key201"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174572"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13309"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19071890"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.06.025"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12566"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201176"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.10.037"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2014.03.014"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0906-7"},{"key":"e_1_3_2_35_2","first-page":"S76","article-title":"Macrovascular involvement in systemic sclerosis: evidence of correlation with disease activity","volume":"30","author":"Zeng Y","year":"2012","unstructured":"Zeng Y, Li M, Xu D, Hou Y, Wang Q, Fang Q, Sun Q, Zhang S, Zeng X. Macrovascular involvement in systemic sclerosis: evidence of correlation with disease activity. Clin Exp Rheumatol. 2012;30:S76\u2013S80.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0267-5"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003319710387918"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1422.030"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.10.2183"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.018283"},{"key":"e_1_3_2_41_2","first-page":"469","article-title":"Limited scleroderma is associated with increased prevalence of macrovascular disease","volume":"22","author":"Youssef P","year":"1995","unstructured":"Youssef P, Brama T, Englert H, Bertouch J. Limited scleroderma is associated with increased prevalence of macrovascular disease. J Rheumatol. 1995;22:469\u2013472.","journal-title":"J Rheumatol"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4267"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes352"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket377"},{"key":"e_1_3_2_45_2","first-page":"313","article-title":"Incident atrial fibrillation in systemic sclerosis: the predictive role of B\u2010type natriuretic peptide","volume":"55","author":"Giallafos I","year":"2014","unstructured":"Giallafos I, Triposkiadis F, Oikonomou E, Giamouzis G, Aggeli K, Konstantopoulou P, Kouranos V, Mavrikakis M, Giallafos J, Stefanadis C, Sfikakis PP. Incident atrial fibrillation in systemic sclerosis: the predictive role of B\u2010type natriuretic peptide. Hellenic J Cardiol. 2014;55:313\u2013321.","journal-title":"Hellenic J Cardiol"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2396"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.103382"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.068"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000221"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100245"},{"key":"e_1_3_2_51_2","first-page":"31","article-title":"Pulmonary hypertension in systemic sclerosis: prevalence, incidence and predictive factors in a large multicentric Italian cohort","volume":"31","author":"Iudici M","year":"2013","unstructured":"Iudici M, Codullo V, Giuggioli D, Riccieri V, Cuomo G, Breda S, Manfredi A, Iannace N, D'Alto M, Ghio S, Rossi R, Vizza CD, Caporali R, Valesini G, Ferri C, Valentini G. Pulmonary hypertension in systemic sclerosis: prevalence, incidence and predictive factors in a large multicentric Italian cohort. Clin Exp Rheumatol. 2013;31:31\u201336.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24525"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90044-8"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.91.1.118"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.11.001"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.095836"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90008-4"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0277-2"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(90)90126-P"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2016.1192217"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61306-8"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_3_2_63_2","first-page":"1573","article-title":"Criteria for the classification of early systemic sclerosis","volume":"28","author":"LeRoy EC","year":"2001","unstructured":"LeRoy EC, Medsger TA Jr. Criteria for the classification of early systemic sclerosis. J Rheumatol. 2001;28:1573\u20131576.","journal-title":"J Rheumatol"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.136929"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204424"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200103)44:3<735::AID-ANR125>3.0.CO;2-F"},{"key":"e_1_3_2_67_2","first-page":"754","article-title":"Improving the sensitivity of the American College of Rheumatology classification criteria for systemic sclerosis","volume":"25","author":"Hudson M","year":"2007","unstructured":"Hudson M, Taillefer S, Steele R, Dunne J, Johnson SR, Jones N, Mathieu JP, Baron M. Improving the sensitivity of the American College of Rheumatology classification criteria for systemic sclerosis. Clin Exp Rheumatol. 2007;25:754\u2013757.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu530"},{"key":"e_1_3_2_69_2","first-page":"2454","article-title":"Influence of clinical features, serum antinuclear antibodies, and lung function on survival of patients with systemic sclerosis","volume":"28","author":"Jacobsen S","year":"2001","unstructured":"Jacobsen S, Ullman S, Shen GQ, Wiik A, Halberg P. Influence of clinical features, serum antinuclear antibodies, and lung function on survival of patients with systemic sclerosis. J Rheumatol. 2001;28:2454\u20132459.","journal-title":"J Rheumatol"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.013405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:36:02Z","timestamp":1715600162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.013405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":68,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2019,9,3]]}},"alternative-id":["10.1161\/JAHA.119.013405"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.013405","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]},"assertion":[{"value":"2019-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e013405"}}