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The present study investigated the importance of aspirin in inhibiting the abnormal activation of platelets and promoting the normal function of the vascular endothelium in a rat model of salt\u2010sensitive hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Method and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Dahl salt\u2010sensitive rats and salt\u2010resistant rats were fed a normal\u2010salt diet (4% NaCl), a high\u2010salt diet (8% NaCl), or a high\u2010salt diet with aspirin gavage (10\u00a0mg\/kg per day) for 8\u00a0weeks. Blood pressure, platelet activation, vascular function, inflammatory response, and potential mechanism were measured. Low\u2010dose aspirin (10\u00a0mg\/kg per day) decreased the high\u2010salt diet\u2013induced elevation of blood pressure, platelet activation, leukocyte infiltration, and leukocyte\u2013platelet aggregation (\n              <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n              45+\n              <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n              61+), as well as vascular endothelial and renal damage. These effects were related to the ability of aspirin to prevent the adhesion of leukocytes to endothelial cells via inhibition of the platelet cyclooxygenase 1 but not the cyclooxygenase 2 pathway. Aspirin also reversed the high\u2010salt diet\u2013induced abnormal activation of complement and coagulation cascades in platelets.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">These results highlight a new property of aspirin in ameliorating vascular endothelial dysfunction induced by platelet activation, which may be beneficial in the treatment of salt\u2010sensitive hypertension.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013470","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T10:00:29Z","timestamp":1576749629000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Low\u2010Dose Aspirin Treatment Attenuates Male Rat Salt\u2010Sensitive Hypertension via Platelet Cyclooxygenase 1 and Complement Cascade Pathway"],"prefix":"10.1161","volume":"9","author":[{"given":"Xiaoliang","family":"Jiang","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Sciences CAMS&amp;PUMC) Beijing China"},{"name":"Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Liu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Sciences CAMS&amp;PUMC) Beijing China"},{"name":"Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Sciences CAMS&amp;PUMC) Beijing China"},{"name":"Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxian","family":"Wu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Sciences CAMS&amp;PUMC) Beijing China"},{"name":"Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"Jose","sequence":"additional","affiliation":[{"name":"Division of Kidney Diseases &amp; Hypertension Department of Medicine The George Washington University School of Medicine &amp; Health Sciences Washington DC"},{"name":"Department of Pharmacology and Physiology The George Washington University School of Medicine &amp; Health Sciences Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hypertension Henan Provincial People's Hospital People's Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Yang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Sciences CAMS&amp;PUMC) Beijing China"},{"name":"Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.03.007"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13517"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1160\/th15-10-0791"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2009.04.001"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2015.1064881"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.307074"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/157016112801784602"},{"key":"e_1_3_1_9_2","first-page":"2468","article-title":"Correlation between platelet\u2010derived growth factor signaling pathway and inflammation in desoxycorticosterone\u2010induced salt\u2010sensitive hypertensive rats with myocardial fibrosis","volume":"6","author":"Fan B","year":"2013","unstructured":"Fan B, Ma L, Li Q, Wang L, Zhou J, Wu J. 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