{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:41:55Z","timestamp":1753882915629,"version":"3.41.2"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Because of the increasing numbers of congenital patients surviving into adulthood, early diagnosis and prevention of acquired cardiovascular disease is reasonable. The aim of this study was to detect diagnostic subgroups of adults with congenital heart disease (ACHD) that have increased carotid intima\u2010media thickness (\n              <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n              ), a subclinical marker of cardiovascular damage.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This study enrolled 831\n              <jats:styled-content style=\"fixed-case\">ACHD<\/jats:styled-content>\n              patients (392 women, aged 38.8\u00b111.7\u00a0years) from May 2015 to February 2019 at their regular outpatient visit. Far wall\n              <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n              was measured using a semiautomatic ultrasound system at 4 angles. Age, sex, height, weight, blood pressure, smoking status, and antihypertensive medication were registered and entered in a multiple linear regression model to compare diagnostic subgroups to 191 healthy controls (111 women, aged 36.7\u00b113.5\u00a0years). There were no significant differences in\n              <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n              of\n              <jats:styled-content style=\"fixed-case\">ACHD<\/jats:styled-content>\n              (0.538\u00b10.086\u00a0mm) compared with healthy controls (0.541\u00b10.083\u00a0mm;\n              <jats:italic>P<\/jats:italic>\n              =0.649) after adjusting for the aforementioned covariates. Only patients with coarctation of the aorta showed significantly higher\n              <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n              values (0.592\u00b10.075\u00a0mm;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) compared with healthy controls. In addition,\n              <jats:styled-content style=\"fixed-case\">ACHD<\/jats:styled-content>\n              patients who were men (\n              <jats:italic>P<\/jats:italic>\n              =0.032), older (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and were prescribed antihypertensive medications (\n              <jats:italic>P<\/jats:italic>\n              =0.003) were all found to have thicker\n              <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n              values.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Overall, we determined that within the\n              <jats:styled-content style=\"fixed-case\">ACHD<\/jats:styled-content>\n              cohort, only those patients with a history of coarctation have higher\n              <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n              values. To better determine the mechanism of abnormal vasculature, further basic research is needed.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013536","type":"journal-article","created":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T10:00:15Z","timestamp":1579946415000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Is Carotid Intima\u2010Media Thickness Increased in Adults With Congenital Heart Disease?"],"prefix":"10.1161","volume":"9","author":[{"given":"Barbara","family":"Reiner","sequence":"first","affiliation":[{"name":"Department of Paediatric Cardiology and Congenital Heart Disease German Heart Centre Munich Technical University Munich Munich Germany"},{"name":"Institute of Preventive Pediatrics Technical University Munich Munich 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