{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T18:58:03Z","timestamp":1772909883962,"version":"3.50.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,11,19]]},"abstract":"\n Background<\/jats:title>\n \n The choice of optimal drug\u2010eluting stent therapy for patients with diabetes mellitus (\n DM<\/jats:styled-content>\n ) undergoing percutaneous coronary intervention remains uncertain. We aimed to assess the long\u2010term clinical outcomes after percutaneous coronary intervention with biodegradable polymer sirolimus\u2010eluting stents (\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n ) versus durable polymer everolimus\u2010eluting stents (\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n ) in patients with\n DM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In a prespecified subgroup analysis of the\n BIOSCIENCE<\/jats:styled-content>\n (Ultrathin Strut Biodegradable Polymer Sirolimus\u2010Eluting Stent Versus Durable Polymer Everolimus\u2010Eluting Stent for Percutaneous Coronary Revascularization) trial (\n NCT<\/jats:styled-content>\n 01443104), patients randomly assigned to ultrathin\u2010strut\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n or thin\u2010strut\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n were stratified according to diabetic status. The primary end point was target lesion failure, a composite of cardiac death, target vessel myocardial infarction, and clinically indicated target lesion revascularization, at 5\u00a0years. Among 2119 patients, 486 (22.9%) presented with\n DM<\/jats:styled-content>\n . Compared with individuals without DM, patients with\n DM<\/jats:styled-content>\n were older and had a greater baseline cardiac risk profile. In patients with DM, target lesion failure at 5\u00a0years occurred in 74 patients (cumulative incidence, 31.0%) treated with\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n and 57 patients (25.8%) treated with\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n (risk ratio, 1.23; 95%\n CI<\/jats:styled-content>\n , 0.87\u20131.73 [\n P<\/jats:italic>\n =0.24]). In individuals without DM, target lesion failure at 5\u00a0years occurred in 124 patients (16.8%) treated with\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n and 132 patients (16.8%) treated with\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n (risk ratio, 0.98; 95%\n CI,<\/jats:styled-content>\n 0.77\u20131.26 [\n P<\/jats:italic>\n =0.90;\n P<\/jats:italic>\n for interaction=0.31]). Cumulative 5\u2010year incidence rates of cardiac death, target vessel myocardial infarction, clinically indicated target lesion revascularization, and definite stent thrombosis were similar among patients with DM treated with\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n or\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n . There was no interaction between diabetic status and treatment effect of\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n versus\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In a prespecified subgroup analysis of the\n BIOSCIENCE<\/jats:styled-content>\n trial, we found no difference in clinical outcomes throughout 5\u00a0years between patients with DM treated with ultrathin\u2010strut\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n or thin\u2010strut\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n https:\/\/www.clinicaltrials.gov\/<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 01443104.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.013607","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T10:06:06Z","timestamp":1573121166000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Five\u2010Year Outcomes in Patients With Diabetes Mellitus Treated With Biodegradable Polymer Sirolimus\u2010Eluting Stents Versus Durable Polymer Everolimus\u2010Eluting Stents"],"prefix":"10.1161","volume":"8","author":[{"given":"Juan F.","family":"Iglesias","sequence":"first","affiliation":[{"name":"Division of Cardiology Geneva University Hospitals Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dik","family":"Heg","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine and Clinical Trials Unit Bern University Hospital Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Roffi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Geneva University Hospitals Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"T\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Cardiology Triemlispital Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Lanz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bern University Hospital Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Rigamonti","sequence":"additional","affiliation":[{"name":"Division of Cardiology Geneva University Hospitals Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igal","family":"Moarof","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital Aarau Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Cardiology University and Hospital Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Weilenmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital St Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Cardiology Basel University Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florim","family":"Cuculi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital Luzern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Valgimigli","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bern University Hospital Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"J\u00fcni","sequence":"additional","affiliation":[{"name":"Department of Medicine and Institute of Health Policy, Management and Evaluation Applied Health Research Centre Li Ka Shing Knowledge Institute of St Michael's Hospital University of Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bern University Hospital Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pilgrim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bern University Hospital Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140721.27004.4B"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.17.2126"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.03.059"},{"key":"e_1_3_1_5_2","first-page":"40:87","article-title":"2018 ESC\/EACTS Guidelines on myocardial revascularization","author":"Neumann FJ","year":"2019","unstructured":"Neumann FJ, Sousa\u2010Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, Byrne RA, Collet JP, Falk V, Head SJ, J\u00fcni P, Kastrati A, Koller A, Kristensen SD, Niebauer J, Richter DJ, Seferovic PM, Sibbing D, Stefanini GG, Windecker S, Yadav R, Zembala MO; ESC Scientific Document Group . 2018 ESC\/EACTS Guidelines on myocardial revascularization. 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