{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:00Z","timestamp":1787018100913,"version":"build-2736575974"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,3,3]]},"abstract":"\n Background<\/jats:title>\n \n Intravascular ultrasound (\n IVUS<\/jats:styled-content>\n ) guidance during percutaneous coronary intervention (\n PCI<\/jats:styled-content>\n ) offers tomographic images of the coronary vessels, allowing optimization of stent implantation at the time of\n PCI<\/jats:styled-content>\n . However, the long\u2010term beneficial effect of\n IVUS<\/jats:styled-content>\n over\n PCI<\/jats:styled-content>\n guided by coronary angiography (\n CA<\/jats:styled-content>\n ) alone remains under question. We sought to investigate the outcomes of\n IVUS<\/jats:styled-content>\n \u2010guided compared with\n CA<\/jats:styled-content>\n \u2010guided\n PCI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We performed a comprehensive search of PubMed, Medline, and Cochrane Central Register, looking for randomized controlled trials and observational studies that compared\n PCI<\/jats:styled-content>\n outcomes of\n IVUS<\/jats:styled-content>\n with\n CA<\/jats:styled-content>\n . Data were aggregated for the primary outcome measure using the random\u2010effects model as pooled risk ratio (\n RR<\/jats:styled-content>\n ). The primary outcomes were the rate of cardiovascular death, need for target lesion revascularization, occurrence of myocardial infarction, and rate of stent thrombosis. A total of 19 studies met the inclusion criteria, comprising 27\u00a0610 patients divided into\n IVUS<\/jats:styled-content>\n (n=11\u00a0513) and\n CA<\/jats:styled-content>\n (n=16\u00a0097). Compared with standard\n CA<\/jats:styled-content>\n \u2010guided\n PCI<\/jats:styled-content>\n , we found that the risks of cardiovascular death (\n RR<\/jats:styled-content>\n , 0.63; 95%\n CI<\/jats:styled-content>\n , 0.54\u20130.73), myocardial infarction (\n RR<\/jats:styled-content>\n , 0.71; 95%\n CI<\/jats:styled-content>\n , 0.58\u20130.86), target lesion revascularization (\n RR<\/jats:styled-content>\n , 0.81; 95%\n CI<\/jats:styled-content>\n , 0.70\u20130.94), and stent thrombosis (\n RR<\/jats:styled-content>\n , 0.57; 95%\n CI<\/jats:styled-content>\n , 0.41\u20130.79) were all significantly lower using\n IVUS<\/jats:styled-content>\n guidance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Compared with standard\n CA<\/jats:styled-content>\n \u2010guided\n PCI<\/jats:styled-content>\n , the use of\n IVUS<\/jats:styled-content>\n imaging guidance to optimize stent implantation is associated with a reduced risk of cardiovascular death and major adverse events, such as myocardial infarction, target lesion revascularization, and stent thrombosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.013678","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T05:00:13Z","timestamp":1582174813000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":149,"title":["Intravascular Ultrasound Imaging\u2013Guided Versus Coronary Angiography\u2013Guided Percutaneous Coronary Intervention: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"9","author":[{"given":"Fahed","family":"Darmoch","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center\/Harvard School of Medicine Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Chadi","family":"Alraies","sequence":"additional","affiliation":[{"name":"Detroit Medical Center Wayne State University Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Al\u2010Khadra","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homam","family":"Moussa Pacha","sequence":"additional","affiliation":[{"name":"MedStar Washington Hospital Center Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane S.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center\/Harvard School of Medicine Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Osborn","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center\/Harvard School of Medicine Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07493-4"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.09.042"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00249-6"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.5.523"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.9.1043"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000043240.87526.3F"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.108.799494"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-1144"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780121403"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-018-0495-9"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-7-5"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I12A245"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.108.778647"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24601"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.01.227"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.002592"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.09.014"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.06.017"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.03.059"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S65768"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22244"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.05.027"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.15454"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.11.009"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.07.005"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3701.096064"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn249"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.013"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2012.00744.x"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003942"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.09.030"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.12.043"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I7A129"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-015-0144-8"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.10.002"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.04.154"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.09.013"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.003700"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0843-z"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27673"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001952"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22273"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.012"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-015-0670-4"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31922-5"},{"key":"e_1_3_1_48_2","unstructured":"ClincalTrial.gov National Library of Medicine OPtical Coherence Tomography (OCT) Guided Coronary Stent IMplantation Compared to Angiography: a Multicenter Randomized TriaL in PCI 2020. Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03507777."}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.013678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:33:26Z","timestamp":1715585606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.013678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,3]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,3,3]]}},"alternative-id":["10.1161\/JAHA.119.013678"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.013678","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,3]]},"assertion":[{"value":"2019-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e013678"}}