{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:09:18Z","timestamp":1792098558400,"version":"4.4.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,3,3]]},"abstract":"\n Background<\/jats:title>\n \n Primary aldosteronism (\n PA<\/jats:styled-content>\n ) is associated with higher atrial fibrillation prevalence and other cardiovascular complications. However, the effect of target treatment to prevent new\u2010onset atrial fibrillation (\n NOAF<\/jats:styled-content>\n ) remains unclear. This study investigated incidence of\n NOAF<\/jats:styled-content>\n under different treatment strategies in patients with PA.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We analyzed longitudinal data for patients with\n PA<\/jats:styled-content>\n without atrial fibrillation history from 1997 to 2009 within the National Health Insurance Research Database in Taiwan. Patients with essential hypertension matched by propensity score were enrolled as controls. The primary outcome measurement was\n NOAF<\/jats:styled-content>\n , and secondary outcome measurements were mortality, major cardiac and cardiac\/cerebrovascular events, and a combined end point of\n NOAF<\/jats:styled-content>\n and mortality. We identified 2202 patients with\n PA<\/jats:styled-content>\n (534 adrenalectomy, 1668 mineralocorticoid receptor antagonist [MRA] therapy) and 8808 essential hypertension controls with mean follow\u2010up of 4.4\u00a0years. In primary outcome measurement, patients with\n PA<\/jats:styled-content>\n who underwent adrenalectomy had a lower incidence of\n NOAF<\/jats:styled-content>\n (adjusted hazard ratio; 0.28,\n P<\/jats:italic>\n =0.011) than controls. In contrast, the patients with PA who received\n MRA<\/jats:styled-content>\n therapy had comparable risk of\n NOAF<\/jats:styled-content>\n (adjusted hazard ratio, 1.20;\n P<\/jats:italic>\n =0.224). In secondary outcome measurement, patients with PA who underwent adrenalectomy had a lower rate of mortality and combined end point of\n NOAF<\/jats:styled-content>\n and mortality than controls. Patients with PA who received\n MRA<\/jats:styled-content>\n therapy had a higher risk of mortality, major cardiac and cardiac\/cerebrovascular events, and combined\n NOAF<\/jats:styled-content>\n with mortality than the essential hypertension controls.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Compared with patients with essential hypertension, patients with PA who underwent adrenalectomy had a lower incidence of\n NOAF<\/jats:styled-content>\n . However, this finding was not observed in patients with PA who received\n MRA<\/jats:styled-content>\n therapy with a lower dose. Differences between the 2 strategies may reduce with a higher dose of\n MRA<\/jats:styled-content>\n therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.013699","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T09:10:16Z","timestamp":1582103416000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Influence of Different Treatment Strategies on New\u2010Onset Atrial Fibrillation Among Patients With Primary Aldosteronism: A Nationwide Longitudinal Cohort\u2010Based Study"],"prefix":"10.1161","volume":"9","author":[{"given":"Chien\u2010Ting","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Yun\u2010Lin Branch Yun\u2010Lin Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che\u2010Wei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Internal 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