{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:08:41Z","timestamp":1780643321444,"version":"3.54.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,12,17]]},"abstract":"\n Background<\/jats:title>\n \n Chronic kidney disease is associated with structural and compositional abnormalities in high\u2010density lipoprotein particles (HDLp). We examined associations of HDLp size, particle subfractions, and apolipoprotein C\u2010\n III<\/jats:styled-content>\n content with incident cardiovascular disease (\n CVD<\/jats:styled-content>\n ) events across categories of estimated glomerular filtration rate (\n eGFR<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Analyses included 6699 participants in MESA (Multi\u2010Ethnic Study of Atherosclerosis) with measurements of HDLp and 5723 participants with measurements of\n HDL<\/jats:styled-content>\n apolipoprotein C\u2010\n III<\/jats:styled-content>\n . Cox\u2010regression methods were used to evaluate associations between HDLp and apolipoproteins with\n CVD<\/jats:styled-content>\n events. Larger HDLp size was associated with lower\n CVD<\/jats:styled-content>\n risk in participants with lower\n eGFR<\/jats:styled-content>\n : hazard ratio (95%\n CI<\/jats:styled-content>\n ) per SD higher mean\n HDL<\/jats:styled-content>\n size was 1.00 (0.90\u20131.11) in\n eGFR<\/jats:styled-content>\n \u226560\u00a0mL\/min per 1.73\u00a0m\n 2<\/jats:sup>\n , 0.65 (0.48\u20130.86) in\n eGFR<\/jats:styled-content>\n 45 to 59 mL\/min per 1.73\u00a0m\n 2<\/jats:sup>\n , and 0.48 (0.25\u20130.93) in\n eGFR<\/jats:styled-content>\n <45 mL\/min per 1.73\u00a0m\n 2<\/jats:sup>\n (\n P<\/jats:italic>\n for interaction=0.05). Associations of HDLp subfractions with\n CVD<\/jats:styled-content>\n varied significantly by\n eGFR<\/jats:styled-content>\n (\n P<\/jats:italic>\n for interaction=0.04), with significant inverse associations between higher concentrations of large HDLp and\n CVD<\/jats:styled-content>\n events across categories of kidney function, but nonsignificant results for small HDLp. Only HDLp without apolipoprotein C\u2010\n III<\/jats:styled-content>\n was associated with lower risk of\n CVD<\/jats:styled-content>\n events, with seemingly (albeit not statistically significant) stronger associations among participants with lower\n eGFR<\/jats:styled-content>\n (\n P<\/jats:italic>\n for interaction=0.19).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n HDL<\/jats:styled-content>\n particles of larger size and higher concentrations of large\n HDL<\/jats:styled-content>\n and of\n HDL<\/jats:styled-content>\n without apolipoprotein C\u2010\n III<\/jats:styled-content>\n were associated with lower\n CVD<\/jats:styled-content>\n risk, with risk estimates seemingly stronger among participants with lower\n eGFR<\/jats:styled-content>\n . Future larger studies are needed to corroborate these findings.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.013713","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T10:00:37Z","timestamp":1575972037000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Association of High\u2010Density Lipoprotein Particles and High\u2010Density Lipoprotein Apolipoprotein C\u2010III Content With Cardiovascular Disease Risk According to Kidney Function: The Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1161","volume":"8","author":[{"given":"Julio A.","family":"Lamprea\u2010Montealegre","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Kidney Research Institute University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L.","family":"McClelland","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Otvos","sequence":"additional","affiliation":[{"name":"Laboratory Corporation of America Holdings Morrisville NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Mora","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular and Preventive Medicine Center for Lipid Metabolomics Brigham and Women's Hospital and Harvard Medical School Harvard University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manja","family":"Koch","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health Harvard University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majken K.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health Harvard University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Department of Epidemiology Kidney Research Institute University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017070798"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2015.05.009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.36"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.300935"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000217"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0500"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.9.1450"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031276"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M011163"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.05.020"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114248"},{"key":"e_1_3_2_14_2","first-page":"171","article-title":"Measurement of lipoprotein subclass profiles by nuclear magnetic resonance spectroscopy","volume":"48","author":"Otvos JD","year":"2002","unstructured":"Otvos JD. Measurement of lipoprotein subclass profiles by nuclear magnetic resonance spectroscopy. Clin Lab. 2002;48:171\u2013180.","journal-title":"Clin Lab"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.111.000232"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P073288"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007824"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.255828"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.05.007"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P900003-JLR200"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5286"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.09.008"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.591743"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.108753"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312794"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.02.006"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00730116"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013050482"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.013713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:28:26Z","timestamp":1715599706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.013713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,17]]},"references-count":27,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2019,12,17]]}},"alternative-id":["10.1161\/JAHA.119.013713"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.013713","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,17]]},"assertion":[{"value":"2019-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e013713"}}