{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:37:27Z","timestamp":1792640247162,"version":"4.5.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">It is recognized that factors beyond aortic size are important in predicting outcome in abdominal aortic aneurysm (AAA) disease. AAA is characterized by the breakdown of elastin within the aortic tunica media, leading to aortic dilatation and rupture. The aim of this study was to investigate the association of plasma desmosine (pDES), an elastin\u2010specific degradation product, with disease severity and clinical outcome in patients with AAA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We measured pDES and serum biomarker concentrations in 507 patients with AAAs (94% men; mean age, 72.4\u00b16.1\u00a0years; mean AAA diameter, 48\u00b18\u00a0mm) and 162 control subjects (100% men; mean age, 71.5\u00b14.4\u00a0years) from 2 observational cohort studies. In the longitudinal cohort study (n=239), we explored the incremental prognostic value of pDES on AAA events. pDES was higher in patients with AAA compared with control subjects (mean\u00b1SD: 0.46\u00b10.22 versus 0.33\u00b10.16\u00a0ng\/mL;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and had the strongest correlation with AAA diameter (\n              <jats:italic>r<\/jats:italic>\n              =0.39;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) of any serum biomarker. After adjustment for baseline AAA diameter, pDES was associated with an AAA event (hazard ratio, 2.03 per SD increase [95% CI, 1.02\u20134.02];\n              <jats:italic>P<\/jats:italic>\n              =0.044). In addition to AAA diameter, pDES provided incremental improvement in risk stratification (continuous net reclassification improvement, 34.4% [95% CI, \u221210.8% to 57.5%;\n              <jats:italic>P<\/jats:italic>\n              =0.09]; integrated discrimination improvement, 0.04 [95% CI, 0.00\u20130.15;\n              <jats:italic>P<\/jats:italic>\n              =0.050]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">pDES concentrations predict disease severity and clinical outcomes in patients with AAA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              http:\/\/\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.isrctn.com\">www.isrctn.com<\/jats:ext-link>\n              . Unique identifier: ISRCTN76413758.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013743","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T09:06:05Z","timestamp":1570611965000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Plasma Desmosine and Abdominal Aortic Aneurysm Disease"],"prefix":"10.1161","volume":"8","author":[{"given":"Ify R.","family":"Mordi","sequence":"first","affiliation":[{"name":"Division of Molecular and Clinical Medicine University of Dundee Dundee United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael O.","family":"Forsythe","sequence":"additional","affiliation":[{"name":"British Heart Foundation\/University of Edinburgh Centre for Cardiovascular Science Edinburgh United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corry","family":"Gellatly","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences and National Institute for Health Research Leicester Biomedical Research Centre University of Leicester Glenfield Hospital Leicester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid","family":"Iskandar","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine University of Dundee Dundee United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia M.","family":"McBride","sequence":"additional","affiliation":[{"name":"British Heart Foundation\/University of Edinburgh Centre for Cardiovascular Science Edinburgh United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Saratzis","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences and National Institute for Health Research Leicester Biomedical Research Centre University of Leicester Glenfield Hospital Leicester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod","family":"Chalmers","sequence":"additional","affiliation":[{"name":"British Heart Foundation\/University of Edinburgh Centre for Cardiovascular Science Edinburgh United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Science National Heart Center Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Bown","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences and National Institute for Health Research Leicester Biomedical Research Centre University of Leicester Glenfield Hospital Leicester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Newby","sequence":"additional","affiliation":[{"name":"British Heart Foundation\/University of Edinburgh Centre for Cardiovascular Science Edinburgh United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chim C.","family":"Lang","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine University of Dundee Dundee United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey T. J.","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Systems Medicine University of Dundee Dundee United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Maria","family":"Choy","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine University of Dundee Dundee United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.08.091"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.03.435"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr0905244"},{"key":"e_1_3_2_5_2","first-page":"CD002945","article-title":"Screening for abdominal aortic aneurysm","author":"Cosford PA","year":"2007","unstructured":"Cosford PA, Leng GC. Screening for abdominal aortic aneurysm. Cochrane Database Syst Rev. 2007:CD002945.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.6663"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199909000-00002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.10.104"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.10.023"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.07.031"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308779"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2016.00001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-3-200502010-00012"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.802074"},{"key":"e_1_3_2_15_2","first-page":"266","article-title":"Circulating biomarkers for abdominal aortic aneurysm: what did we learn in the last decade?","volume":"32","author":"Moris DN","year":"2013","unstructured":"Moris DN, Georgopoulos SE. Circulating biomarkers for abdominal aortic aneurysm: what did we learn in the last decade? Int Angiol. 2013;32:266\u2013280.","journal-title":"Int Angiol"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502454"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331970005100505"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000085631.76095.64"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.304361"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.001131"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007791"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1329"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1516"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1404"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00174807"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032344"},{"key":"e_1_3_2_27_2","unstructured":"University of Leicester . The United Kingdom Aneurysm Growth Study (UKAGS)\u2014Study Information. Available at: http:\/\/www2.le.ac.uk\/projects\/ukags. Accessed September 23 2019."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028433"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2016.10.013"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10721"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.4155\/bio.13.164"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(97)80219-5"},{"key":"e_1_3_2_33_2","first-page":"CD001835","article-title":"Surgery for small asymptomatic abdominal aortic aneurysms","volume":"2","author":"Filardo G","year":"2015","unstructured":"Filardo G, Powell JT, Martinez MA, Ballard DJ. Surgery for small asymptomatic abdominal aortic aneurysms. Cochrane Database Syst Rev. 2015;2:CD001835.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-013-9845-5"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1850"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.05.009"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306538"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2000.1151"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1027OC"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200279"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8707"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.10.006"},{"key":"e_1_3_2_43_2","unstructured":"Office for National Statistics . Deaths registered in England and Wales (series DR). 2016; 2018. Available at: https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/deaths\/bulletins\/deathsregistrationsummarytables\/2016. Accessed September 23 2019."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.08.125"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31222-4"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.013743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:30:52Z","timestamp":1715599852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.013743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":44,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2019,10,15]]}},"alternative-id":["10.1161\/JAHA.119.013743"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.013743","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,15]]},"assertion":[{"value":"2019-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e013743"}}