{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:01:40Z","timestamp":1792191700639,"version":"4.4.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"\n Background<\/jats:title>\n \n In the 2000s, adults with\n HIV<\/jats:styled-content>\n had a higher risk for atherosclerotic cardiovascular disease (\n ASCVD<\/jats:styled-content>\n ) compared with those without\n HIV<\/jats:styled-content>\n . There is uncertainty if this excess risk still exists in the United States given changes in antiretroviral therapies and increased statin use.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We compared the risk for\n ASCVD<\/jats:styled-content>\n events between\n US<\/jats:styled-content>\n adults aged \u226519\u00a0years with and without\n HIV<\/jats:styled-content>\n who had commercial or supplemental Medicare health insurance between January 1, 2011, and December 31, 2016. Beneficiaries with\n HIV<\/jats:styled-content>\n (n=82\u00a0426) were frequency matched 1:4 on age, sex, and calendar year to those without\n HIV<\/jats:styled-content>\n (n=329\u00a0704). Beneficiaries with and without\n HIV<\/jats:styled-content>\n were followed up through December 31, 2016, for\n ASCVD<\/jats:styled-content>\n events, including myocardial infarction, stroke, and lower extremity artery disease hospitalizations. Most beneficiaries were aged <55\u00a0years (79%) and men (84%). Over a median follow\u2010up of 1.6\u00a0years (maximum, 6\u00a0years), there were 3287\n ASCVD<\/jats:styled-content>\n events, 2190 myocardial infarctions, 891 strokes, and 322 lower extremity artery disease events. The rate per 1000\u00a0person\u2010years among beneficiaries with and without\n HIV<\/jats:styled-content>\n was 5.53 and 3.49 for\n ASCVD<\/jats:styled-content>\n , respectively, 3.58 and 2.34 for myocardial infarction, respectively, 1.49 and 0.94 for stroke, respectively, and 0.65 and 0.31 for lower extremity artery disease hospitalizations, respectively. The multivariable\u2010adjusted hazard ratio (95%\n CI<\/jats:styled-content>\n ) for\n ASCVD<\/jats:styled-content>\n , myocardial infarction, stroke, and lower extremity artery disease hospitalizations comparing beneficiaries with versus without\n HIV<\/jats:styled-content>\n was 1.29 (1.18\u20131.40), 1.26 (1.13\u20131.39), 1.30 (1.11\u20131.52), and 1.46 (1.11\u20131.92), respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Adults with\n HIV<\/jats:styled-content>\n in the United States continue to have a higher\n ASCVD<\/jats:styled-content>\n risk compared with their counterparts without\n HIV<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.013744","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T22:00:22Z","timestamp":1577484022000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Excess Risk for Atherosclerotic Cardiovascular Outcomes Among US Adults With HIV in the Current Era"],"prefix":"10.1161","volume":"9","author":[{"given":"Robert S.","family":"Rosenson","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetria","family":"Hubbard","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keri L.","family":"Monda","sequence":"additional","affiliation":[{"name":"Amgen, Inc Thousand Oaks CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Reading","sequence":"additional","affiliation":[{"name":"Amgen, Inc Thousand Oaks CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligong","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Dluzniewski","sequence":"additional","affiliation":[{"name":"Amgen, Inc Thousand Oaks CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greer A.","family":"Burkholder","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Muntner","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisandro D.","family":"Colantonio","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","unstructured":"Division of HIV\/AIDS Prevention National Center for HIV\/AIDS VH STD and TB Prevention . 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