{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:36:16Z","timestamp":1775770576970,"version":"3.50.1"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,9,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Adults with a systemic right ventricle (\n              <jats:styled-content style=\"fixed-case\">sRV<\/jats:styled-content>\n              ) have a high risk of cardiac complications. This study aimed to identify prognostic markers in adults with\n              <jats:styled-content style=\"fixed-case\">sRV<\/jats:styled-content>\n              based on clinical evaluation, echocardiography, and blood biomarkers.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this prospective cohort study, consecutive clinically stable adults with\n              <jats:styled-content style=\"fixed-case\">sRV<\/jats:styled-content>\n              caused by Mustard\u2010 or congenitally corrected transposition of the great arteries were included (2011\u20132013). Eighty\u2010six patients were included (age 37\u00b19\u00a0years, 65% male, 83% New York Heart Association functional class I, 76% Mustard transposition of the great arteries, 24% congenitally corrected transposition of the great arteries). Venous blood sampling was performed including N\u2010terminal pro B\u2010type natriuretic peptide, high\u2010sensitive\u2010troponin\u2010T, high\u2010sensitivity C\u2010reactive protein, growth differentiation factor\u201015, galectin\u20103, red cell distribution width, estimated glomerular filtration rate, and hemoglobin. Besides conventional echocardiographic measurements, longitudinal, circumferential, and radial strain were assessed using strain analysis. During a median follow\u2010up of 5.9 (interquartile range 5.3\u20136.3) years, 19 (22%) patients died or had heart failure (primary end point) and 29 (34%) patients died or had arrhythmia (secondary end point). Univariable Cox regression analysis was performed using dichotomous or standardized continuous variables. New York Heart Association functional class &gt;I, systolic blood pressure, and most blood biomarkers were associated with the primary and secondary end point (galectin\u20103 not for primary, N\u2010terminal pro B\u2010type natriuretic peptide and high\u2010sensitivity C\u2010reactive protein not for secondary end point). Growth differentiation factor\u201015 showed the strongest association with both end points (hazard ratios; 2.44 [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.67\u20133.57,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001], 2.00 [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.46\u20132.73,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001], respectively). End\u2010diastolic basal dimension of the subpulmonary ventricle was associated with both end points (hazard ratio: 1.95 [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.34\u20132.85],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001, 1.70 [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.21\u20132.38,\n              <jats:italic>P<\/jats:italic>\n              =0.002], respectively). Concerning strain analysis, only\n              <jats:styled-content style=\"fixed-case\">sRV<\/jats:styled-content>\n              septal strain was associated with the secondary end point (hazard ratio 0.58 [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.39\u20130.86],\n              <jats:italic>P<\/jats:italic>\n              =0.006).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Clinical, conventional echocardiographic, and blood measurements are important markers for risk stratification in adults with a\n              <jats:styled-content style=\"fixed-case\">sRV<\/jats:styled-content>\n              . The value of novel echocardiographic strain analysis seems limited.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013745","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T09:02:07Z","timestamp":1566378127000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Exploring the Prognostic Value of Novel Markers in Adults With a Systemic Right Ventricle"],"prefix":"10.1161","volume":"8","author":[{"given":"Laurie W.","family":"Geenen","sequence":"first","affiliation":[{"name":"Department of Cardiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roderick W. J.","family":"van Grootel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korhan","family":"Akman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivan J. M.","family":"Baggen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrthe E.","family":"Menting","sequence":"additional","affiliation":[{"name":"Department of Radiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannet A.","family":"Eindhoven","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A. A. E.","family":"Cuypers","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"},{"name":"Department of Clinical Epidemiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemien E.","family":"van den Bosch","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolien W.","family":"Roos\u2010Hesselink","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus MC University Medical Centre Rotterdam 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