{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:43:52Z","timestamp":1792622632761,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,12,3]]},"abstract":"\n Background<\/jats:title>\n \n Guidelines recommend heart team discussion and coronary artery bypass graft consideration in patients with proximal left anterior descending (\n LAD<\/jats:styled-content>\n ) artery stenosis. Evidence suggests that outcomes of proximal\n LAD<\/jats:styled-content>\n angioplasty might not differ from treatment of nonproximal\n LAD<\/jats:styled-content>\n locations. We aim to determine clinical outcomes of patients undergoing percutaneous coronary intervention in the proximal\n LAD<\/jats:styled-content>\n segment in comparison with nonproximal\n LAD<\/jats:styled-content>\n angioplasty, using a thin\u2010strut drug\u2010eluting stent.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In this analysis of the e\u2010Ultimaster registry, patients undergoing angioplasty in the proximal\n LAD<\/jats:styled-content>\n territory were compared with those treated in nonproximal\n LAD<\/jats:styled-content>\n locations. Multivariate analysis and propensity score were used to adjust for differences among the groups. The primary outcome was target lesion failure: a composite of cardiac death, target\u2010lesion\u2013related myocardial infarction, and\/or clinically driven target lesion revascularization at 1\u2010year follow\u2010up. Of the 17\u00a0805 patients (mean age, 64.2\u00b111; 76% male), 5452 (30.6%) underwent proximal\n LAD<\/jats:styled-content>\n and 12\u00a0353 (69.4%) nonproximal\n LAD<\/jats:styled-content>\n percutaneous coronary intervention. Patients in the proximal\n LAD<\/jats:styled-content>\n group had more multivessel disease (48.7% versus 43.5%;\n P<\/jats:italic>\n <0.001) and 2\u2010fold more bifurcations lesions (18.8% versus 9.2%;\n P<\/jats:italic>\n <0.0001). After propensity\u2010weighted adjustment, target lesion failure did not differ between the groups (3.3% versus 2.9%;\n P<\/jats:italic>\n =0.17 for proximal\n LAD<\/jats:styled-content>\n versus nonproximal\n LAD<\/jats:styled-content>\n angioplasty, respectively). In multivariate analysis, proximal\n LAD<\/jats:styled-content>\n treatment was not an independent predictor of target lesion failure (odds ratio, 1.07; 95% CI, 0.88\u20131.31;\n P<\/jats:italic>\n =0.48).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n At 1\u2010year follow\u2010up, patients had similar clinical outcomes independent of stenting location, questioning whether proximal\n LAD<\/jats:styled-content>\n treatment should be regarded differently from stenting in any other coronary artery territory.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.013786","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T11:16:18Z","timestamp":1575285378000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Proximal Left Anterior Descending Artery Treatment Using a Bioresorbable Polymer Coating Sirolimus\u2010Eluting Stent: Real\u2010World Outcomes From the Multicenter Prospective e\u2010Ultimaster Registry"],"prefix":"10.1161","volume":"8","author":[{"given":"Pablo","family":"Codner","sequence":"first","affiliation":[{"name":"Department of Cardiology Hillel Yaffe Medical Center Hadera Israel"},{"name":"The Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majdi","family":"Saada","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hillel Yaffe Medical Center Hadera Israel"},{"name":"The Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orazbek","family":"Sakhov","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology City Heart Center Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawed","family":"Polad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jeroen Bosch Hospital \u2018s\u2010Hertogenbosch The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazila Tun\u2010Nesa","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Heart Foundation Hospital & Research Institute Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzad","family":"Munir","sequence":"additional","affiliation":[{"name":"Department of Cardiology Royal Wolverhampton Hospital Wolverhampton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamas","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group Center of Prognosis Research Institute of Primary Care Sciences Keele University Stoke on Trent United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Crowley","sequence":"additional","affiliation":[{"name":"Galway University Hospital Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Monsegu","sequence":"additional","affiliation":[{"name":"Institut Cardiovasculaire Groupe Hospitalier Mutualiste de Grenoble Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Perez","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Grant Benavente Concepcion Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasko","family":"Kedev","sequence":"additional","affiliation":[{"name":"University Clinic of Cardiology Skopje Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Austin","sequence":"additional","affiliation":[{"name":"James Cook University Hospital Middleborough United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Roguin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hillel Yaffe Medical Center Hadera Israel"},{"name":"The Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"e\u2010Ultimaster 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