{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:44:59Z","timestamp":1769013899252,"version":"3.49.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Obesity and atrial fibrillation (\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              ) frequently coexist and independently increase mortality. We sought to assess the association between obesity and adverse events in patients receiving oral anticoagulants for\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Consecutive\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              outpatients receiving anticoagulant agents (both vitamin K antagonists and direct oral anticoagulants) were recruited into the\n              <jats:styled-content style=\"fixed-case\">FANTASIIA<\/jats:styled-content>\n              (Atrial fibrillation: influence of the level and type of anticoagulation on the incidence of ischemic and hemorrhagic stroke) registry. This observational, multicenter, and prospective registry of\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              patients analyzes the quality of anticoagulation, incidence of events, and differences between oral anticoagulant therapies. We analyzed baseline patient characteristics according to body mass index, normal: &lt;25\u00a0kg\/m\n              <jats:sup>2<\/jats:sup>\n              , overweight: 25\u201330\u00a0kg\/m\n              <jats:sup>2<\/jats:sup>\n              , and obese: \u226530\u00a0kg\/m\n              <jats:sup>2<\/jats:sup>\n              ), assessing all\u2010cause mortality, stroke, major bleeding and major adverse cardiovascular events (a composite of ischemic stroke, myocardial infarction, and total mortality) at 3\u00a0years\u2019 follow\u2010up. In this secondary prespecified substudy, the association of weight on prognosis was evaluated. We recruited 1956 patients (56% men, mean age 73.8\u00b19.4\u00a0years): 358 (18.3%) had normal body mass index, 871 (44.5%) were overweight, and 727 (37.2%) were obese. Obese patients were younger (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and had more comorbidities. Mean time in the therapeutic range was similar across body mass index categories (\n              <jats:italic>P<\/jats:italic>\n              =0.42). After a median follow\u2010up of 1070\u00a0days, 255 patients died (13%), 45 had a stroke (2.3%), 146 a major bleeding episode (7.5%) and 168 a major adverse cardiovascular event (8.6%). Event rates were similar between groups for total mortality (\n              <jats:italic>P<\/jats:italic>\n              =0.29), stroke (\n              <jats:italic>P<\/jats:italic>\n              =0.90), major bleeding (\n              <jats:italic>P<\/jats:italic>\n              =0.31), and major adverse cardiovascular events (\n              <jats:italic>P<\/jats:italic>\n              =0.24). On multivariate Cox analysis, body mass index was not independently associated with all\u2010cause mortality, cardiovascular mortality, stroke, major bleeding, or major adverse cardiovascular events.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this prospective cohort of patients anticoagulated for\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              , obesity was highly prevalent and was associated with more comorbidities, but not with poor prognosis.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013789","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T10:00:21Z","timestamp":1577181621000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Association of Body Mass Index With Clinical Outcomes in Patients With Atrial Fibrillation: A Report From the FANTASIIA Registry"],"prefix":"10.1161","volume":"9","author":[{"given":"Vicente","family":"Bertomeu\u2010Gonzalez","sequence":"first","affiliation":[{"name":"Department of Cardiology Hospital Universitario de San Juan de Alicante Universidad Miguel Hern\u00e1ndez Alicante Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Enfermedades Cardiovasculares: CIBER\u2010CV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Moreno\u2010Arribas","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario de San Juan de Alicante Universidad Miguel Hern\u00e1ndez Alicante Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Enfermedades Cardiovasculares: CIBER\u2010CV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Asunci\u00f3n","family":"Esteve\u2010Pastor","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario Virgen de la Arrixaca Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca) Murcia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Enfermedades Cardiovasculares: CIBER\u2010CV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Rold\u00e1n\u2010Rabad\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital La Paz Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Enfermedades Cardiovasculares: CIBER\u2010CV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Ciencias de la Salud Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC) Universidade da Coru\u00f1a La Coru\u00f1a Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Enfermedades Cardiovasculares: CIBER\u2010CV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Ra\u00f1a\u2010M\u00edguez","sequence":"additional","affiliation":[{"name":"ODDS, SL A Coru\u00f1a Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn","family":"Ruiz\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Reina Sof\u00eda C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"Cequier","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital de Bellvitge Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Enfermedades Cardiovasculares: CIBER\u2010CV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Bertomeu\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario de San Juan de Alicante Universidad Miguel Hern\u00e1ndez Alicante Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Enfermedades Cardiovasculares: CIBER\u2010CV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Badim\u00f3n","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center (CSIC\u2010ICCC) Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Enfermedades Cardiovasculares: CIBER\u2010CV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Anguita","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Reina Sof\u00eda C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart &amp; Chest Hospital Liverpool United Kingdom"},{"name":"Aalborg Thrombosis Research Unit Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario Virgen de la Arrixaca Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca) Murcia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Enfermedades Cardiovasculares: CIBER\u2010CV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"FANTASIIA Study Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.11.123"},{"key":"e_1_3_1_3_2","first-page":"6930","article-title":"Obesity in the European region: social aspects, epidemiology and preventive strategies","volume":"22","author":"Ricci G","year":"2018","unstructured":"Ricci G, Tomassoni D, Pirillo I, Sirignano A, Sciotti M, Zaami S, Grappasonni I. 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