{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:07:37Z","timestamp":1790352457190,"version":"4.1.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Reports on sex differences in stroke outcome and risk factors are scarce in Latin America. Our objective was to analyze clinical and prognostic differences according to sex among participants in the\n              <jats:styled-content style=\"fixed-case\">LASE<\/jats:styled-content>\n              (Latin American Stroke Registry).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Nineteen centers across Central and South America compiled data on demographics, vascular risk factors, clinical stroke description, ancillary tests, and functional outcomes at short\u2010term follow\u2010up of patients included from January 2012 to January 2017. For the present study, all these variables were analyzed according to sex at hospital discharge. We included 4788 patients with a median in\u2010hospital stay of 8\u00a0days (interquartile range, 5\u20138); 2677 were male (median age, 66\u00a0years) and 2111 female (median age, 60\u00a0years). Ischemic stroke occurred in 4293: 3686 as cerebral infarction (77%) and 607 as transient ischemic attack cases (12.7%); 495 patients (10.3%) corresponded to intracerebral hemorrhage. Poor functional outcome (modified Rankin scale, 3\u20136) was present in 1662 (34.7%) patients and 38.2% of women (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Mortality was present in 6.8% of the registry, with 7.8% in women compared with 6.0% in men (\n              <jats:italic>P<\/jats:italic>\n              =0.01). Death and poor functional outcome for all\u2010type stroke showed a higher risk in female patients (hazard ratio, 1.3,\n              <jats:italic>P<\/jats:italic>\n              =0.03; and hazard ratio, 1.1,\n              <jats:italic>P<\/jats:italic>\n              =0.001, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A worse functional outcome and higher mortality rates occurred in women compared with men in the\n              <jats:styled-content style=\"fixed-case\">LASE<\/jats:styled-content>\n              , confirming sex differences issues at short\u2010term follow\u2010up.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013903","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T10:00:34Z","timestamp":1581933634000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Sex Differences Among Participants in the Latin American Stroke Registry"],"prefix":"10.1161","volume":"9","author":[{"given":"Antonio","family":"Arauz","sequence":"first","affiliation":[{"name":"Stroke Department Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Suarez M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Serrano","sequence":"additional","affiliation":[{"name":"Stroke Department Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Suarez M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n F.","family":"Ameriso","sequence":"additional","affiliation":[{"name":"Institute for Neurological Research FLENI Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Pujol\u2010Lereis","sequence":"additional","affiliation":[{"name":"Institute for Neurological Research FLENI Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Flores","sequence":"additional","affiliation":[{"name":"Neurology Department Facultad de Ciencias Medicas Universidad Nacional de Asunci\u00f3n Asunci\u00f3n Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1n","family":"Bayona","sequence":"additional","affiliation":[{"name":"Stroke Center Neurology Department Hospital Universitario Fundaci\u00f3n Santa Fe de Bogot\u00e1 Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huberth","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Neurosciences Department Hospital Dr. Rafael Calder\u00f3n Guardia (CCSS) San Jos\u00e9 Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Castillo","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital General 450 Durango M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Ecos","sequence":"additional","affiliation":[{"name":"Neurology Department Instituto Nacional de Ciencias Neurol\u00f3gicas Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Hospital Regional PEMEX Ciudad Madero M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Amaya","sequence":"additional","affiliation":[{"name":"Neurology Department Fundaci\u00f3n Cl\u00ednica Valle del Lili\/Universidad Icesi Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica","family":"Ru\u00edz","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Ju\u00e1rez M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minerva","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital General de M\u00e9xico M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Zapata","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Nacional Guillermo Almenara Irigoyen Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Roa","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Universitario Mayor Mederi Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Marquez\u2010Romero","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital General de Zona 2\u2010IMSS Aguascalientes M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Morelos","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Regional del ISSSTE Morelia M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Regional del ISSSTE Morelia M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Leon","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Regional Dr. Valent\u00edn G\u00f3mez Far\u00edas\u2010ISSSTE Guadalajara M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Romero","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Pablo Arturo Suarez Quito Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Ru\u00edz\u2010Sandoval","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Civil Fray Antonio Alcade Guadalajara Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Reyes","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Hospital Central Norte\u2010PEMEX M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Barboza","sequence":"additional","affiliation":[{"name":"Neurosciences Department Hospital Dr. Rafael Calder\u00f3n Guardia (CCSS) San Jos\u00e9 Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Valencia\u2010Ch\u00e1vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda P.","family":"Rosa Calle\u2010La","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Abanto\u2010Argomedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Benavides\u2010V\u00e1squez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Otiniano\u2010Sinfuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Mernes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Valderrama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos F.","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime E.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda V.","family":"Ropero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"German","family":"L\u00f3pez\u2010Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Gonzalez\u2010Oscoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Arteaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Mendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Torrealba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30030-4"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30034-1"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319831483"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2011.01514.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.540781"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.484618"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00174"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000157662.09551.e5"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804492"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000082999"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.07.006"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000441103"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010235"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2018.7171"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.543157"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30073-4"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60834-3"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022786"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13995"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70193-5"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000381832"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.whi.2017.08.006"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30994-2"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2013.01.016"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6773.12705"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30068-7"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.013903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:28:02Z","timestamp":1715599682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.013903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,2,18]]}},"alternative-id":["10.1161\/JAHA.119.013903"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.013903","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"2019-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e013903"}}