{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:40:24Z","timestamp":1791913224746,"version":"4.3.4"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Diagnostic criteria of flow\u2010mediated vasodilation (FMD), an index of endothelial function, and nitroglycerin\u2010induced vasodilation (NID), an index of vascular smooth muscle function, of the brachial artery have not been established. The purpose of this study was to propose diagnostic criteria of FMD and NID for normal endothelial function and normal vascular smooth muscle function.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We investigated the cutoff values of FMD and NID in subjects with (risk group) and those without cardiovascular risk factors or cardiovascular diseases (no\u2010risk group) in 7277 Japanese subjects (mean age 51.4\u00b110.8\u00a0years) from the Flow\u2010Mediated Dilation Japan study and the Flow\u2010Mediated Dilatation Japan Registry study for analysis of the cutoff value of FMD and in 1764 Japanese subjects (62.2\u00b116.1\u00a0years) from the registry of Hiroshima University Hospital for analysis of the cutoff value of NID. Receiver\u2010operator characteristic curve analysis of FMD to discriminate subjects in the no\u2010risk group from patients in the risk group showed that the optimal cutoff value of FMD to diagnose subjects in the no\u2010risk group was 7.1%. Receiver\u2010operator characteristic curve analysis of NID to discriminate subjects in the no\u2010risk group from patients in the risk group showed that the optimal cutoff value of NID to diagnose subjects in the no\u2010risk group was 15.6%.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">We propose that the cutoff value for normal endothelial function assessed by FMD of the brachial artery is 7.1% and that the cutoff value for normal vascular smooth muscle function assessed by NID of the brachial artery is 15.6% in Japanese subjects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.umin.ac.jp\">www.umin.ac.jp<\/jats:ext-link>\n              Unique identifiers: UMIN000012950, UMIN000012951, UMIN000012952, and UMIN000003409\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.013915","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T10:00:25Z","timestamp":1578477625000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":123,"title":["Diagnostic Criteria of Flow\u2010Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin\u2010Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery"],"prefix":"10.1161","volume":"9","author":[{"given":"Tatsuya","family":"Maruhashi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima 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