{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:16:31Z","timestamp":1789146991258,"version":"build-2803163510"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with muscular dystrophy (\n              <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n              ) represent a vulnerable patient population with no clearly defined care model in modern\u2010day clinical practice to manage a high burden of heart disease and comorbidities. We demonstrate the effectiveness of cardiac interventions, namely the initiation and optimization of medical and device therapies, as part of a multidisciplinary care approach to improve clinical outcomes in patients with\n              <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We conducted a prospective cohort study at the Neuromuscular Multidisciplinary clinic following patients with dystrophinopathies, limb\u2010girdle\n              <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n              , type 1 myotonic dystrophy, and facioscapulohumeral\n              <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n              . A negative control group classified as non\u2010\n              <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n              myopathies without heart disease, was also tracked. Our cohort of 185 patients (median age: 42\u00a0years; 79 [42.7%] women), included 145 patients with\n              <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n              . Cardiomyopathy was present in 65.6% of the patients with dystrophinopathies (21 of 32) and 27.3% of the patients with limb\u2010girdle\n              <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n              (9 of 33). Conduction abnormalities were common in type 1 myotonic dystrophy (33.3% [20\/60] patients). Cardiac intervention reversed systolic dysfunction, with left ventricular ejection fraction improving from 43% to 50.0% over a 3\u2010year period. A sustained reduction in healthcare utilization was also observed. The number of outpatient clinic visits decreased from 3.0 to 1.5\u00a0visits per year, the duration of hospitalizations was reduced from 14.2 to 0.9\u00a0days per year, and the number of cardiac\u2010related hospitalizations decreased from 0.4 to 0.1\u00a0hospitalizations per year associated with low mortality.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Our study demonstrates that cardiac intervention as part of a comprehensive multidisciplinary care approach to treating patients with\n              <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n              leads to a sustained improvement in clinical outcomes.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014004","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T10:00:31Z","timestamp":1578996031000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Cardiac Intervention Improves Heart Disease and Clinical Outcomes in Patients With Muscular Dystrophy in a Multidisciplinary Care Setting"],"prefix":"10.1161","volume":"9","author":[{"given":"Anish","family":"Nikhanj","sequence":"first","affiliation":[{"name":"Division of Cardiology Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"},{"name":"Mazankowski Alberta Heart Institute Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haran","family":"Yogasundaram","sequence":"additional","affiliation":[{"name":"Division of Cardiology Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"},{"name":"Mazankowski Alberta Heart Institute Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey","family":"Miskew Nichols","sequence":"additional","affiliation":[{"name":"Division of Cardiology Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"},{"name":"Mazankowski Alberta Heart Institute Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Richman\u2010Eisenstat","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Phan","sequence":"additional","affiliation":[{"name":"Division of Neurology Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Bakal","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaeem A.","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"Division of Neurology Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin Y.","family":"Oudit","sequence":"additional","affiliation":[{"name":"Division of Cardiology Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"},{"name":"Mazankowski Alberta Heart Institute Faculty of Medicine and Dentistry University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/JND-170280"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70272-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.2182"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.004960"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.078"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90116-3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062800"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.6807"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060343"},{"key":"e_1_3_2_11_2","first-page":"1","article-title":"Genetic basis of limb\u2010girdle muscular dystrophies: the 2014 update","volume":"33","author":"Nigro V","year":"2014","unstructured":"Nigro V, Savarese M. 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