{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:46:32Z","timestamp":1780721192158,"version":"3.54.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"\n Background<\/jats:title>\n \n The circulating level of soluble lectin\u2010like oxidized low\u2010density lipoprotein receptor\u20101 (\n sLOX<\/jats:styled-content>\n \u20101) is a valuable biomarker of acute myocardial infarction (\n AMI<\/jats:styled-content>\n ). The most electronegative low\u2010density lipoprotein, L5, signals through\n LOX<\/jats:styled-content>\n \u20101 to trigger atherogenesis. We examined the characteristics of\n LOX<\/jats:styled-content>\n \u20101 and the role of L5 in aspirated coronary thrombi of\n AMI<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Intracoronary thrombi were aspirated by performing interventional thrombosuction in patients with\n ST<\/jats:styled-content>\n \u2010segment\u2013elevation myocardial infarction (\n STEMI<\/jats:styled-content>\n ; n=32) or non\u2013ST\u2010segment\u2013elevation myocardial infarction (n=12).\n LOX<\/jats:styled-content>\n \u20101 level and the ratio of\n sLOX<\/jats:styled-content>\n \u20101 to membrane\u2010bound\n LOX<\/jats:styled-content>\n \u20101 were higher in thrombi of\n STEMI<\/jats:styled-content>\n patients than in those of non\u2013ST\u2010segment\u2013elevation myocardial infarction patients. In all aspirated thrombi,\n LOX<\/jats:styled-content>\n \u20101 colocalized with apoB100. When we explored the role of L5 in\n AMI<\/jats:styled-content>\n , deconvolution microscopy showed that particles of L5 but not L1 (the least electronegative low\u2010density lipoprotein) quickly formed aggregates prone to retention in thrombi. Treating human monocytic\n THP<\/jats:styled-content>\n \u20101 cells with L5 or L1 showed that L5 induced cellular adhesion and promoted the differentiation of monocytes into macrophages in a dose\u2010dependent manner. In a second cohort of\n AMI<\/jats:styled-content>\n patients, the L5 percentage and plasma concentration of\n sLOX<\/jats:styled-content>\n \u20101 were higher in\n STEMI<\/jats:styled-content>\n patients (n=33) than in non\u2013ST\u2010segment\u2013elevation myocardial infarction patients (n=25), and\n sLOX<\/jats:styled-content>\n \u20101 level positively correlated with L5 level in\n AMI<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The level of\n LOX<\/jats:styled-content>\n \u20101 and the ratio of\n sLOX<\/jats:styled-content>\n \u20101 to membrane\u2010bound\n LOX<\/jats:styled-content>\n \u20101 in aspirated thrombi, as well as the circulating level of\n sLOX<\/jats:styled-content>\n \u20101 were higher in\n STEMI<\/jats:styled-content>\n patients than in non\u2013ST\u2010segment\u2013elevation myocardial infarction patients. L5 may play a role in releasing a high level of\n sLOX<\/jats:styled-content>\n \u20101 into the circulation of\n STEMI<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014008","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T10:00:16Z","timestamp":1578909616000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Detection of a High Ratio of Soluble to Membrane\u2010Bound LOX\u20101 in Aspirated Coronary Thrombi From Patients With ST\u2010Segment\u2013Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"9","author":[{"given":"An\u2010Sheng","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine Mackay Medical College New Taipei City Taiwan"},{"name":"Cardiovascular Research Laboratory China Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Laboratory China Medical University Hospital Taichung Taiwan"},{"name":"Division of Cardiovascular Medicine Asia University Hospital Taichung Taiwan"},{"name":"Department of Biotechnology Asia University Taichung Taiwan"},{"name":"Division of Cardiovascular Medicine China Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Sheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine China Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010Hang","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine China Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Ming","family":"Chang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Laboratory China Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lu","sequence":"additional","affiliation":[{"name":"Vascular and Medicinal Research Texas Heart Institute Houston TX"},{"name":"InVitro Cell Research LLC Englewood NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Burns","sequence":"additional","affiliation":[{"name":"College of Optometry University of Houston Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu\u2010Huang","family":"Chen","sequence":"additional","affiliation":[{"name":"Vascular and Medicinal Research Texas Heart Institute Houston TX"},{"name":"New York Heart Research Foundation Mineola NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Kakino","sequence":"additional","affiliation":[{"name":"Department of Life Innovation Institute for Biomedical Sciences Shinshu University Matsumoto Japan"},{"name":"Department of Molecular Pathophysiology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Department of Life Innovation Institute for Biomedical Sciences Shinshu University Matsumoto Japan"},{"name":"Department of Molecular Pathophysiology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Laboratory China Medical University Hospital Taichung Taiwan"},{"name":"Division of Cardiovascular Medicine China Medical University Hospital Taichung Taiwan"},{"name":"Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198010163031601"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000135267.82813.52"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401444"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302721"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.010"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/386073a0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.09.006"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.04.110"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009874"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/716325"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.32466"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000071350.78872.C4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1351\/PAC-CON-10-12-07"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.243923"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065220.70220.F7"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.190116"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt062"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182742c84"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00489-5"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000157141.00778.AC"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.2.171"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.11.5573-5578.1999"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.1.3.177"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/107424840200700304"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.04.016"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.4.1107"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225016074"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-019-0211-5"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.24.3110"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-504639"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-646117"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.468397"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.140707"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7176"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5674"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.11.2995"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.9.2995"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.50.31700"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.8.2713"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00236-X"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-0904"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608143150703"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/181324"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:01:07Z","timestamp":1715601667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.014008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,21]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,1,21]]}},"alternative-id":["10.1161\/JAHA.119.014008"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.014008","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,21]]},"assertion":[{"value":"2019-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e014008"}}