{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:47:08Z","timestamp":1792669628262,"version":"4.5.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Hypothermia has been associated with therapeutic benefits including reduced mortality and better neurologic outcomes in survivors of cardiac arrest. However, undesirable side effects have been reported in patients undergoing coronary interventions. Using a large animal model of temperature management, we aimed to describe how temperature interferes with the coronary vasculature.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Coronary hemodynamics and endothelial function were studied in 12 pigs at various core temperatures. Left circumflex coronary artery was challenged with intracoronary nitroglycerin, bradykinin, and adenosine at normothermia (38\u00b0C) and mild hypothermia (34\u00b0C), followed by either rewarming (38\u00b0C; n=6) or moderate hypothermia (Mo\n              <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n              ; 32\u00b0C, n=6). Invasive coronary hemodynamics by Doppler wire revealed a slower coronary blood velocity at 32\u00b0C in the Mo\n              <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n              protocol (normothermia 20.2\u00b111.2\u00a0cm\/s versus mild hypothermia 18.7\u00b14.3\u00a0cm\/s versus Mo\n              <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n              11.3\u00b15.3\u00a0cm\/s,\n              <jats:italic>P<\/jats:italic>\n              =0.007). Mo\n              <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n              time point was also associated with high values of hyperemic microvascular resistance (&gt;3\u00a0mm\u00a0Hg\/cm per second) (normothermia 2.0\u00b10.6\u00a0mm\u00a0Hg\/cm per second versus mild hypothermia 2.0\u00b10.8\u00a0mm\u00a0Hg\/cm per second versus Mo\n              <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n              3.4\u00b11.6\u00a0mm\u00a0Hg\/cm per second,\n              <jats:italic>P<\/jats:italic>\n              =0.273). Assessment of coronary vasodilation by quantitative coronary analysis showed increased endothelium\u2010dependent (bradykinin) vasodilation at 32\u00b0C when compared with normothermia (normothermia 6.96% change versus mild hypothermia 9.01% change versus Mo\n              <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n              25.42% change,\n              <jats:italic>P<\/jats:italic>\n              =0.044). Results from coronary reactivity in\u00a0vitro were in agreement with angiography data and established that endothelium\u2010dependent relaxation in Mo\n              <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n              completely relies on NO production.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this porcine model of temperature management, 34\u00b0C hypothermia and rewarming (38\u00b0C) did not affect coronary hemodynamics or endothelial function. However, 32\u00b0C hypothermia altered coronary vasculature physiology by slowing coronary blood flow, increasing microvascular resistance, and exacerbating endothelium\u2010dependent vasodilatory response.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014035","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T11:12:30Z","timestamp":1580728350000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Moderate Hypothermia Modifies Coronary Hemodynamics and Endothelium\u2010Dependent Vasodilation in a Porcine Model of Temperature Management"],"prefix":"10.1161","volume":"9","author":[{"given":"Joaquim","family":"Bobi","sequence":"first","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Cardiology Department Institut Cl\u00ednic Cardiovascular Hospital Cl\u00ednic de Barcelona University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Solanes","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Cardiology Department Institut Cl\u00ednic Cardiovascular Hospital Cl\u00ednic de Barcelona University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Dantas","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Cardiology Department Institut Cl\u00ednic Cardiovascular Hospital Cl\u00ednic de Barcelona University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Cardiology Department Institut Cl\u00ednic Cardiovascular Hospital Cl\u00ednic de Barcelona University of Barcelona Spain"},{"name":"Department of Internal Medicine and Cardiology Kitasato University School of Medicine Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ander","family":"Regueiro","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Cardiology Department Institut Cl\u00ednic Cardiovascular Hospital Cl\u00ednic de Barcelona University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Castillo","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Cardiology Department Institut Cl\u00ednic Cardiovascular Hospital Cl\u00ednic de Barcelona University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Sabat\u00e9","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Cardiology Department Institut Cl\u00ednic Cardiovascular Hospital Cl\u00ednic de Barcelona University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rigol","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Cardiology Department Institut Cl\u00ednic Cardiovascular Hospital Cl\u00ednic de Barcelona University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Freixa","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Cardiology Department Institut Cl\u00ednic Cardiovascular Hospital Cl\u00ednic de Barcelona University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2006.01.017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007588"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.33"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012689"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003289"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282173"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.14380"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2014.02.013"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.07.037"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-14-30"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189442"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.12.224"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.01.050"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.029"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.028"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c160016"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2009.09.012"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005771"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00681.2014"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311431"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.001786"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.05.014"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701067"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007257"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02870-X"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.07.075"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(03)00184-9"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197907000-00022"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2012-1589"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2017.02.015"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2018.04.036"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.06.052"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/2048872614564080"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2006"},{"key":"e_1_3_2_36_2","first-page":"215","article-title":"Regulation of coronary blood flow in health and ischemic heart disease","volume":"27","author":"Duncker DJ","year":"2015","unstructured":"Duncker DJ, Kollerb A, Merkusa D, Canty JMJ. Regulation of coronary blood flow in health and ischemic heart disease. Prog Cardiovasc Dis. 2015;27:215\u2013225.","journal-title":"Prog Cardiovasc Dis"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005361"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.004234"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.08.056"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000078601.79536.6C"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12040"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000050145.25589.65"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.237636"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181aa5241"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2011.08.013"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00994.2009"},{"key":"e_1_3_2_47_2","article-title":"Intensive care medicine research agenda on cardiac arrest","volume":"1","author":"Nolan JP","year":"2017","unstructured":"Nolan JP, Berg RA, Bernard S, Bobrow BJ, Callaway CW, Cronberg T, Koster RW, Kudenchuk PJ, Nichol G, Perkins GD, Rea TD, Sandroni C, Soar J, Sunde K, Cariou A. Intensive care medicine research agenda on cardiac arrest. Intensive Care Med. 2017;1\u201312.","journal-title":"Intensive Care Med"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.06.022"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000630"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.07.016"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000252"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:37:44Z","timestamp":1715600264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.014035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,4]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2,4]]}},"alternative-id":["10.1161\/JAHA.119.014035"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.014035","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,4]]},"assertion":[{"value":"2019-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e014035"}}