{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:26:58Z","timestamp":1769275618202,"version":"3.49.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,12,3]]},"abstract":"\n Background<\/jats:title>\n \n The long\u2010term prognosis of patients with acute myocardial infarction who develop persistent renal dysfunction (\n RD<\/jats:styled-content>\n ) remains unclear. We investigated risk factors and prognostic implications of persistent\n RD<\/jats:styled-content>\n after contrast\u2010induced nephropathy (\n CIN<\/jats:styled-content>\n ) in patients with acute myocardial infarction after primary percutaneous coronary intervention.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We enrolled 952 consecutive patients who underwent primary percutaneous coronary intervention for acute myocardial infarction.\n CIN<\/jats:styled-content>\n was defined as an increase in serum creatinine levels \u22650.5\u00a0mg\/dL or \u226525% from baseline within 72\u00a0hours after percutaneous coronary intervention. Persistent\n RD<\/jats:styled-content>\n was defined as residual impairment of renal function over 2\u00a0weeks, and transient\n RD<\/jats:styled-content>\n was defined as recovery of renal function within 2\u00a0weeks, after\n CIN<\/jats:styled-content>\n . The overall incidence of\n CIN<\/jats:styled-content>\n was 8.8% and that of persistent\n CIN<\/jats:styled-content>\n was 3.1%. A receiver\u2010operator characteristic curve showed that the optimal cutoff value of the contrast volume\/baseline estimated glomerular filtration rate ratio for persistent\n CIN<\/jats:styled-content>\n was 3.45. In multivariable logistic analysis, a contrast volume\/baseline estimated glomerular filtration rate >3.45 was an independent correlate of persistent\n RD<\/jats:styled-content>\n . At 3\u00a0years, the incidence of death was significantly higher in patients with persistent\n RD<\/jats:styled-content>\n than in those with transient\n RD<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.001) and in those without\n CIN<\/jats:styled-content>\n (\n P<\/jats:italic>\n <0.001). Cox regression analysis showed that persistent\n RD<\/jats:styled-content>\n (hazard ratio, 4.99; 95% CI, 2.30\u201310.8;\n P<\/jats:italic>\n <0.001) was a significant risk factor for mortality. A similar trend was observed for the combined end points, which included mortality, hemodialysis, stroke, and acute myocardial infarction.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Persistent\n RD<\/jats:styled-content>\n , but not transient\n RD<\/jats:styled-content>\n , is independently associated with long\u2010term mortality. A contrast volume\/baseline estimated glomerular filtration rate >3.45 is an independent predictor of persistent\n RD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014096","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T10:00:24Z","timestamp":1574762424000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Persistent Renal Dysfunction in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction"],"prefix":"10.1161","volume":"8","author":[{"given":"Kazumasa","family":"Kurogi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Miyazaki Prefectural Nobeoka Hospital Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Miyazaki Prefectural Nobeoka Hospital Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichi","family":"Komaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Miyazaki Prefectural Nobeoka Hospital Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyohei","family":"Marume","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Miyazaki Prefectural Nobeoka Hospital Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Miyazaki Prefectural Nobeoka Hospital Miyazaki 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