{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:11:15Z","timestamp":1790014275408,"version":"4.0.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,11,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Right atrial pressure (\n              <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>\n              ), a composite metric of right ventricular diastolic function, volume status, and right heart compliance, is a predictor of mortality in patients with heart failure due to acquired heart disease. Because patients with tetralogy of Fallot (\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              ) might have abnormal right atrial and ventricular mechanics caused by myocardial injury and remodeling, we hypothesized that\n              <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>\n              would be associated with disease severity and cardiovascular adverse events in this population.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed a cohort study of adults with\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              who underwent right heart catheterization at the Mayo Clinic Rochester between 1990 and 2017. The objective was to determine the association between\n              <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>\n              and multiple domains of disease severity in\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              (percentage of predicted peak oxygen consumption, atrial or ventricular arrhythmia, and heart failure hospitalization), as well as cardiovascular adverse events, defined as sustained ventricular tachycardia, resuscitated or aborted sudden death, heart transplantation, or death. Among 225 patients (113 male; mean age: 39\u00b114\u00a0years), mean RAP was 10.7\u00b15.2\u00a0mm\u00a0Hg and median was 10 mm\u00a0Hg (interquartile range: 7\u201313 mm\u00a0Hg). Increasing\n              <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>\n              was associated with atrial or ventricular arrhythmias (odds ratio: 5.01; 95% CI, 1.22\u201323.49;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), heart failure hospitalization (odds ratio: 1.47; 95% CI, 1.10\u20132.39;\n              <jats:italic>P<\/jats:italic>\n              =0.033) per 5 mm\u00a0Hg, and worsening exercise capacity (peak oxygen consumption;\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0.74,\n              <jats:italic>r<\/jats:italic>\n              =\u22120.86,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n              <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>\n              was a predictor of cardiovascular adverse events (hazard ratio: 1.28; 95% CI, 1.10\u20131.47;\n              <jats:italic>P<\/jats:italic>\n              =0.028) per 5 mm\u00a0Hg.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In symptomatic patients with\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              , increasing\n              <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>\n              correlates with multiple domains of disease severity (risk stratification) and predicts future cardiovascular events (prognostication). These data have potential clinical implications in the target population of symptomatic\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              patients.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014148","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T15:47:52Z","timestamp":1573228072000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Pathophysiologic and Prognostic Implications of Right Atrial Hypertension in Adults With Tetralogy of Fallot"],"prefix":"10.1161","volume":"8","author":[{"given":"Alexander C.","family":"Egbe","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Bonnichsen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh N. V.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason H.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Divison of Pediatric Cardiology Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv741"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2018.04.013"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2018.09.012"},{"key":"e_1_3_1_5_2","first-page":"e637","article-title":"2018 AHA\/ACC guideline for the management of adults with congenital heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"139","author":"Stout KK","year":"2019","unstructured":"Stout KK, Daniels CJ, Aboulhosn JA, Bozkurt B, Broberg CS, Colman JM, Crumb SR, Dearani JA, Fuller S, Gurvitz M, Khairy P, Landzberg MJ, Saidi A, Valente AM, Van Hare GF. 2018 AHA\/ACC guideline for the management of adults with congenital heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;139:e637\u2013e697.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq249"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00351-9"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02566-4"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew082"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.029413"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-3035"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90320-5"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.12.015"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1365"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/4.1.23"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy331"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026807"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.73.3.428"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.02.140"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034740"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2012.11.003"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.6.1775"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.02.025"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.6.1782"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.08.021"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.03.019"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004515"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304958"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.067"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309184"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2212"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313832"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:25:16Z","timestamp":1715599516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.014148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,19]]},"references-count":34,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2019,11,19]]}},"alternative-id":["10.1161\/JAHA.119.014148"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.014148","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,19]]},"assertion":[{"value":"2019-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e014148"}}