{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:12:56Z","timestamp":1790827976695,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,3,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Experimental studies support a link between obesity and pulmonary hypertension (PH), yet clinical studies have been limited. This study sought to determine the association of obesity and pulmonary hemodynamic measures and mortality in PH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We examined patients undergoing right\u2010sided heart catherization (2005\u20132016) in a hospital\u2010based cohort. Multivariable regression models tested associations of body mass index and pulmonary vascular hemodynamics, with PH defined as mean pulmonary artery pressure &gt;20\u00a0mm\u00a0Hg, and further subclassified into precapillary, postcapillary, and mixed PH. Multivariable Cox models were used to examine the effect of PH and obesity on mortality. Among 8940 patients (mean age, 62\u00a0years; 40% women), 52% of nonobese and 69% of obese individuals had evidence of PH. Higher body mass index was independently associated with greater odds of overall PH (odds ratio, 1.34; 95% CI, 1.29\u20131.40;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001 per 5\u2010unit increase in body mass index) as well as each PH subtype (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001 for all). Patients with PH had greater risk of mortality compared with individuals without PH regardless of subgroup (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001 for all). We found that obesity was associated with 23% lower hazard of mortality among patients with PH (hazard ratio, 0.77; 95% CI, 0.69\u20130.85;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). The effect of obesity was greatest among those with precapillary PH (hazard ratio, 0.57; 95% CI, 0.46\u20130.70;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), where obesity modified the effect of PH on mortality (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction=0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Obesity is independently associated with PH. PH is associated with greater mortality; this is modified by obesity such that obese patients with precapillary PH have lower mortality compared with nonobese counterparts. Further studies are needed to elucidate mechanisms underlying obesity\u2010related PH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.119.014195","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T05:00:23Z","timestamp":1582261223000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":90,"title":["Obesity Is Associated With Pulmonary Hypertension and Modifies Outcomes"],"prefix":"10.1161","volume":"9","author":[{"given":"Rachel C.","family":"Frank","sequence":"first","affiliation":[{"name":"Department of Medicine Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Medicine Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazin","family":"Abdelghany","sequence":"additional","affiliation":[{"name":"Department of Medicine Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Paniagua","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Massachusetts General Hospital Boston MA"},{"name":"Corrigan Minehan Heart Center Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romit","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Corrigan Minehan Heart Center Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijeta","family":"Bhambhani","sequence":"additional","affiliation":[{"name":"Corrigan Minehan Heart Center Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Pomerantsev","sequence":"additional","affiliation":[{"name":"Corrigan Minehan Heart Center Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA"},{"name":"Harvard Medical School Harvard University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Ho","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Massachusetts General Hospital Boston MA"},{"name":"Corrigan Minehan Heart Center Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA"},{"name":"Harvard Medical School Harvard University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"1","article-title":"Prevalence of obesity among adults and youth: United States, 2011\u20132014","volume":"219","author":"Ogden CL","year":"2015","unstructured":"Ogden CL, Carroll MD, Fryar CD, Flegal KM. Prevalence of obesity among adults and youth: United States, 2011\u20132014. NCHS Data Brief. 2015;219:1\u20138.","journal-title":"NCHS Data Brief"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.003116"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.051"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.010637"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4801.100076"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.663120"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018935"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181e4f706"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.838698"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001597"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/dcS13-2023"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.02.024"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-3079"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.002026"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020207"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-301992"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.04.051"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.45"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.10.019"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.03.011"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:31:45Z","timestamp":1715585505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.014195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,3]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,3,3]]}},"alternative-id":["10.1161\/JAHA.119.014195"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.014195","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,3]]},"assertion":[{"value":"2019-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e014195"}}