{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:07:41Z","timestamp":1785884861416,"version":"3.56.0"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,6,2]]},"abstract":"\n Background<\/jats:title>\n \n Delivery of hydrogels to the heart is a promising strategy for mitigating the detrimental impact of myocardial infarction (\n MI<\/jats:styled-content>\n ). Challenges associated with the in vivo delivery of currently available hydrogels have limited clinical translation of this technology. Gelatin methacryloyl (Gel\n MA<\/jats:styled-content>\n ) bioadhesive hydrogel could address many of the limitations of available hydrogels. The goal of this proof\u2010of\u2010concept study was to evaluate the cardioprotective potential of Gel\n MA<\/jats:styled-content>\n in a mouse model of\n MI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The physical properties of Gel\n MA<\/jats:styled-content>\n bioadhesive hydrogel were optimized in vitro. Impact of Gel\n MA<\/jats:styled-content>\n bioadhesive hydrogel on post\u2010\n MI<\/jats:styled-content>\n recovery was then assessed in vivo. In 20 mice, Gel\n MA<\/jats:styled-content>\n bioadhesive hydrogel was applied to the epicardial surface of the heart at the time of experimental\n MI<\/jats:styled-content>\n . An additional 20 mice underwent\n MI<\/jats:styled-content>\n but received no Gel\n MA<\/jats:styled-content>\n bioadhesive hydrogel. Survival rates were compared for Gel\n MA<\/jats:styled-content>\n \u2010treated and untreated mice. Left ventricular function was assessed 3\u00a0weeks after experimental\n MI<\/jats:styled-content>\n with transthoracic echocardiography. Left ventricular scar burden was measured with postmortem morphometric analysis. Survival rates at 3\u00a0weeks post\u2010\n MI<\/jats:styled-content>\n were 89% for Gel\n MA<\/jats:styled-content>\n \u2010treated mice and 50% for untreated mice (\n P<\/jats:italic>\n =0.011). Left ventricular contractile function was better in Gel\n MA<\/jats:styled-content>\n \u2010treated than untreated mice (fractional shortening 37% versus 26%,\n P<\/jats:italic>\n <0.001). Average scar burden in Gel\n MA<\/jats:styled-content>\n \u2010treated mice was lower than in untreated mice (6% versus 22%,\n P<\/jats:italic>\n =0.017).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Epicardial Gel\n MA<\/jats:styled-content>\n bioadhesive application at the time of experimental\n MI<\/jats:styled-content>\n was performed safely and was associated with significantly improved post\u2010\n MI<\/jats:styled-content>\n survival compared with control animals. In addition, Gel\n MA<\/jats:styled-content>\n treatment was associated with significantly better preservation of left ventricular function and reduced scar burden.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014199","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T09:06:07Z","timestamp":1590570367000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Gelatin Methacryloyl Bioadhesive Improves Survival and Reduces Scar Burden in a Mouse Model of Myocardial Infarction"],"prefix":"10.1161","volume":"9","author":[{"given":"Leon M.","family":"Ptaszek","sequence":"first","affiliation":[{"name":"Cardiac Arrhythmia Service Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Portillo Lara","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service Massachusetts General Hospital Boston MA"},{"name":"Department of Chemical Engineering Northeastern University Boston MA"},{"name":"Tecnologico de Monterrey Escuela de Ingeniera y Ciensias Zapopan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Shirzaei Sani","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Northeastern University Boston MA"},{"name":"Department of Chemical and Biomolecular Engineering University of California, Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Roh","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejing","family":"Yu","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo A.","family":"Ledesma","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu","family":"Hsiang Yu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Northeastern University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Annabi","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Northeastern University Boston MA"},{"name":"Department of Chemical and Biomolecular Engineering University of California, Los Angeles CA"},{"name":"Center for Minimally Invasive Therapeutics California NanoSystems Institute University of California, Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy N.","family":"Ruskin","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230719"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.28"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.302317"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4428"},{"key":"e_1_3_1_6_2","first-page":"774","article-title":"The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge","volume":"38","author":"Heusch G","year":"2017","unstructured":"Heusch G, Gersh B. 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