{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T01:34:06Z","timestamp":1786671246075,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,4]]},"abstract":"\n Background<\/jats:title>\n \n Myocardial infarction (\n MI<\/jats:styled-content>\n ) size is a key predictor of prognosis in post\u2010\n MI<\/jats:styled-content>\n patients. Cardiovascular magnetic resonance (\n CMR<\/jats:styled-content>\n ) is the gold standard test for\n MI<\/jats:styled-content>\n quantification, but the\n ECG<\/jats:styled-content>\n is less expensive and more widely available. We sought to quantify the relationship between\n ECG<\/jats:styled-content>\n markers and cardiovascular magnetic resonance infarct size.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Patients with prior\n MI<\/jats:styled-content>\n enrolled in the\n DETERMINE<\/jats:styled-content>\n (Defibrillators to Reduce Risk by Magnetic Resonance Imaging Evaluation) and PRE\u2010DETERMINE Trial and Registry were included.\n ECG<\/jats:styled-content>\n leads were analyzed for markers of\n MI<\/jats:styled-content>\n : Q waves, fragmented\n QRS<\/jats:styled-content>\n , and T wave inversion.\n DETERMINE<\/jats:styled-content>\n Score=number of leads with [Q waves\u00d72]+[fragmented\n QRS<\/jats:styled-content>\n ]+[T wave inversion]. Left ventricular ejection fraction (\n LVEF<\/jats:styled-content>\n ) and infarct size as a percentage of left ventricular mass (\n MI<\/jats:styled-content>\n %) were quantified by cardiovascular magnetic resonance. The Modified Selvester Score estimates\n MI<\/jats:styled-content>\n size from 37\n ECG<\/jats:styled-content>\n criteria. In 551 patients (aged 62.1\u00b110.9\u00a0years, 79% men, and\n LVEF<\/jats:styled-content>\n =40.3\u00b111.0%),\n MI<\/jats:styled-content>\n % increased as the number of\n ECG<\/jats:styled-content>\n markers increased (\n P<\/jats:italic>\n <0.001). By univariable linear regression, the\n DETERMINE<\/jats:styled-content>\n Score (range 0\u201326) estimated\n MI<\/jats:styled-content>\n % (\n R<\/jats:italic>\n 2<\/jats:sup>\n =0.18,\n P<\/jats:italic>\n <0.001) with an accuracy approaching that of\n LVEF<\/jats:styled-content>\n (\n R<\/jats:italic>\n 2<\/jats:sup>\n =0.22,\n P<\/jats:italic>\n <0.001) and higher than the Modified Selvester Score (\n R<\/jats:italic>\n 2<\/jats:sup>\n =0.09,\n P<\/jats:italic>\n <0.001). By multivariable linear regression, addition of the\n DETERMINE<\/jats:styled-content>\n Score improved estimation of\n MI<\/jats:styled-content>\n % over\n LVEF<\/jats:styled-content>\n alone (\n P<\/jats:italic>\n <0.001) and over Modified Selvester Score alone (\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients with prior\n MI<\/jats:styled-content>\n , a simple\n ECG<\/jats:styled-content>\n score estimates infarct size and improves infarct size estimation over\n LVEF<\/jats:styled-content>\n alone. Because infarct size is a powerful prognostic indicator, the\n DETERMINE<\/jats:styled-content>\n Score holds promise as a simple and inexpensive risk assessment tool.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014205","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T10:00:33Z","timestamp":1579860033000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Estimating Myocardial Infarction Size With a Simple Electrocardiographic Marker Score"],"prefix":"10.1161","volume":"9","author":[{"given":"Daniel C.","family":"Lee","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Albert","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston 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