{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:26:47Z","timestamp":1792787207352,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,12,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Persistent atrial fibrillation may lead to a higher probability of inappropriate shocks in heart failure patients with an implantable cardioverter\u2010defibrillator (\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              ). The aim of this study was to evaluate the impact of His\u2010Purkinje conduction system pacing combined with atrioventricular node ablation in improving heart function and preventing inappropriate shock therapy in these patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 86 consecutive patients with persistent atrial fibrillation and heart failure who had indications for\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              implantation were enrolled from January 2010 to March 2018. His\u2010Purkinje conduction system pacing with\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              and atrioventricular node ablation was attempted in 55 patients, and the remaining patients underwent\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              implantation only. Left ventricular (LV) ejection fraction, LV end\u2010systolic volume, New York Heart Association (\n              <jats:styled-content style=\"fixed-case\">NYHA<\/jats:styled-content>\n              ) classification, shock therapies, and drug therapy were assessed during follow\u2010up. Overall, 31 patients received\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              implantation with optimal drug therapy (group 1). atrioventricular node ablation combined with His\u2010Purkinje conduction system pacing was successfully achieved in 52 patients (group 2). During follow\u2010up, patients in group 2 had lower incidence of inappropriate shock (15.6% versus 0%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and adverse events (\n              <jats:italic>P<\/jats:italic>\n              =0.011). Meanwhile, improvement in LV ejection fraction and reduction in LV end\u2010systolic volume were significantly higher in group 2 than in group 1 (15% versus 3%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; and 40 versus 2\u00a0mL,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01, respectively).\n              <jats:styled-content style=\"fixed-case\">NYHA<\/jats:styled-content>\n              functional class improved in both groups from a baseline 2.57\u00b10.68 to 1.73\u00b10.74 in group 1 and 2.73\u00b10.59 to 1.42\u00b10.53 in group 2 (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              His\u2010Purkinje conduction system pacing combined with atrioventricular node ablation is feasible and safe with a high success rate in persistent atrial fibrillation patients with heart failure and\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              indication. It can significantly reduce the incidence of inappropriate shocks and improve LV function.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014253","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T10:00:19Z","timestamp":1576231219000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["Feasibility and Efficacy of His Bundle Pacing or Left Bundle Pacing Combined With Atrioventricular Node Ablation in Patients With Persistent Atrial Fibrillation and Implantable Cardioverter\u2010Defibrillator Therapy"],"prefix":"10.1161","volume":"8","author":[{"given":"Songjie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology the First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"Key Lab of Cardiovascular Disease of Wenzhou Wenzhou 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I.","family":"Whinnett","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pugazhendhi","family":"Vijayaraman","sequence":"additional","affiliation":[{"name":"Geisinger Heart Institute Wilkes Barre PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiology the First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"Key Lab of Cardiovascular Disease of Wenzhou Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology the First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"Key Lab of Cardiovascular Disease of Wenzhou Wenzhou 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