{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:47:25Z","timestamp":1791478045411,"version":"4.3.4"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,18]]},"abstract":"\n Background<\/jats:title>\n \n Intravenous ferric carboxymaltose (\n FCM<\/jats:styled-content>\n ) improves symptoms, functional capacity, and quality of life in heart failure and iron deficiency. The mechanisms underlying these effects are not fully understood. The aim of this study was to examine changes in myocardial iron content after\n FCM<\/jats:styled-content>\n administration in patients with heart failure and iron deficiency using cardiac magnetic resonance.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Fifty\u2010three stable heart failure and iron deficiency patients were randomly assigned 1:1 to receive intravenous\n FCM<\/jats:styled-content>\n or placebo in a multicenter, double\u2010blind study. T2* and T1 mapping cardiac magnetic resonance sequences, noninvasive surrogates of intramyocardial iron, were evaluated before and 7 and 30\u00a0days after randomization using linear mixed regression analysis. Results are presented as least\u2010square means with 95% CI. The primary end point was the change in T2* and T1 mapping at 7 and 30\u00a0days. Median age was 73 (65\u201378) years, with N\u2010terminal pro\u2010B\u2010type natriuretic peptide, ferritin, and transferrin saturation medians of 1690\u00a0pg\/mL (1010\u20132828), 63\u00a0ng\/mL (22\u2013114), and 15.7% (11.0\u201319.2), respectively. Baseline T2* and T1 mapping values did not significantly differ across treatment arms. On day 7, both T2* and T1 mapping (ms) were significantly lower in the\n FCM<\/jats:styled-content>\n arm (36.6 [34.6\u201338.7] versus 40 [38\u201342.1],\n P<\/jats:italic>\n =0.025; 1061 [1051\u20131072] versus 1085 [1074\u20131095],\n P<\/jats:italic>\n =0.001, respectively). A similar reduction was found at 30\u00a0days for T2* (36.3 [34.1\u201338.5] versus 41.1 [38.9\u201343.4],\n P<\/jats:italic>\n =0.003), but not for T1 mapping (1075 [1065\u20131085] versus 1079 [1069\u20131089],\n P<\/jats:italic>\n =0.577).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients with heart failure and iron deficiency,\n FCM<\/jats:styled-content>\n administration was associated with changes in the T2* and T1 mapping cardiac magnetic resonance sequences, indicative of myocardial iron repletion.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 03398681.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014254","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T10:00:38Z","timestamp":1581588038000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":83,"title":["Noninvasive Imaging Estimation of Myocardial Iron Repletion Following Administration of Intravenous Iron: The Myocardial\u2010IRON Trial"],"prefix":"10.1161","volume":"9","author":[{"given":"Julio","family":"N\u00fa\u00f1ez","sequence":"first","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario de Valencia Universidad de Valencia INCLIVA Valencia Spain"},{"name":"CIBER Cardiovascular Universitat Jaume I Castell\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Mi\u00f1ana","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital 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