{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:21:57Z","timestamp":1794327717059,"version":"4.9.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Non\u2010alcoholic fatty liver disease (NAFLD) is associated with high cardiovascular morbidity\/mortality, including heart failure. Abnormalities in left ventricular (LV) structure\/function are associated with heart failure risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Participants from the population\u2010based CARDIA (Coronary Artery Risk Development in Young Adults) study year 25 exam (2010\u20132011, aged 43\u201355 years, 61% women, 48% black) with computed tomography measured liver fat and comprehensive echocardiography were included. Echocardiography was repeated at year 30 follow\u2010up (aged 47\u201362 years, N=1827). NAFLD was defined as liver attenuation \u226440 HU after exclusions. LV geometry was classified into normal and abnormal by integrating relative wall thickness and LV mass index. Diastolic function was defined using Doppler and tissue Doppler imaging. Systolic function was assessed with myocardial strain measured by speckle tracking. NAFLD prevalence was 8.7% (n=159). NAFLD participants had higher LV mass, relative wall thickness, incident LV hypertrophy and abnormal LV geometry versus non\u2010NAFLD (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.02). NAFLD participants had impaired LV relaxation (E\/A ratio 1.1 versus 1.2), higher LV filling pressures (E\/e\u2032 ratio 7.9 versus 7.2), worse longitudinal strain (\u221213.9% versus \u221215.3%), and lower LV ejection fraction (58.9% versus 60.2%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01). In multivariable analyses adjusted for heart failure risk factors, NAFLD was independently associated with incident LV hypertrophy (odds ratio: 1.9, 95% CI: 1.1\u20133.4), abnormal LV geometry (odds ratio: 1.9, 1.1\u20133.3) and greater change in strain (odds ratio: 2.2, 1.1\u20134.7). Adjustment for body mass index attenuated associations to non\u2010significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">NAFLD is associated with subclinical changes over time in LV structure\/function and obesity explains much of the association. Presence of obesity in mid\u2010life may identify an important at\u2010risk population in whom to focus preventive heart failure strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.119.014279","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T05:00:24Z","timestamp":1580965224000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":120,"title":["Longitudinal Association of Non\u2010Alcoholic Fatty Liver Disease With Changes in Myocardial Structure and Function: The CARDIA Study"],"prefix":"10.1161","volume":"9","author":[{"given":"Lisa B.","family":"VanWagner","sequence":"first","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"},{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Wilcox","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL"},{"name":"Department of Medicine Division of Cardiology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Alabama Birmingham School of Public Health Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Jeffrey","family":"Carr","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Cardiovascular Medicine and Biomedical Informatics Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Rinella","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv J.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao A. C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Radiology Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Lloyd\u2010Jones","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL"},{"name":"Department of Medicine Division of Cardiology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6891"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi204"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i7.1724"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20781"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.72.618"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09090769"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i12.1848"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.07.042"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25593"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.05.962"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.06.018"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27869"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21879"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2018.09.004"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00630-0"},{"key":"e_1_3_2_17_2","unstructured":"University of Alabama at Birmingham . 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Impairment of the left ventricular systolic and diastolic function\u00a0in\u00a0patients with non\u2010alcoholic fatty liver disease. Cardiol J. 2010;17:457\u201363.","journal-title":"Cardiol J"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000008"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.030"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26610"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:28:15Z","timestamp":1715585295000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.014279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,2,18]]}},"alternative-id":["10.1161\/JAHA.119.014279"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.014279","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"2019-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e014279"}}