{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:17:03Z","timestamp":1787671023627,"version":"build-2736575974"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,6,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Significant variability in morbidity and mortality persists for children with functionally single ventricle congenital heart disease (SV\u2010CHD) despite standardization in medical and surgical care. We hypothesized that maternal health factors may be associated with an increased risk of poor outcomes in children with SV\u2010CHD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This retrospective, observational, cohort study included term maternal\u2010infant pairs with a diagnosis of SV\u2010CHD who underwent surgical palliation from 2006 to 2015 at Primary Children's Hospital. Pairs lacking maternal variables of interest or infant follow\u2010up data were excluded. The association of maternal risk factors of abnormal pre\u2010pregnancy body mass index, abnormal gestational weight gain (&lt;7 or &gt;20\u00a0kg), hypertensive disorders, and gestational diabetes mellitus with death\/transplant and hemodynamics were analyzed using regression models. Of 190 infants, 135 (71%) maternal\u2010infant dyads had complete data for inclusion. Death or transplant occurred in 48 infants (36%) during an average follow\u2010up of 2.2\u00a0years (0.1\u201311.7\u00a0years). Abnormal gestational weight gain was associated with an increased risk of death and\/or transplant in logistic regression (odds ratio, 3.22; 95% CI, 1.32\u20137.86;\n              <jats:italic>P<\/jats:italic>\n              =0.01), but not Cox regression (hazard ratio, 1.9; 95% CI, 1.0\u20133.7;\n              <jats:italic>P<\/jats:italic>\n              =0.055). Mean pulmonary artery pressures were higher in the setting of abnormal gestational weight gain (16.5\u00b12.9 versus 14.7\u00b13.0\u00a0mm\u00a0Hg;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and abnormal pre\u2010pregnancy body mass index (15.7\u00b13.5 versus 14.2\u00b12.1\u00a0mm\u00a0Hg;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) in the systemic right ventricle group.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Abnormal gestational weight gain (excessive or inadequate) is a novel risk factor for worse outcomes in SV\u2010CHD. The fetoplacental environment may alter the trajectory of vascular development to impact outcomes in infants with SV\u2010CHD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014363","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T09:23:46Z","timestamp":1591694626000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Maternal Predictors of Disparate Outcomes in Children With Single Ventricle Congenital Heart Disease"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-6562","authenticated-orcid":false,"given":"Priyanka","family":"Asrani","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelangi M.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Puchalski","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhining","family":"Ou","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Science Study Design and Biostatistics Center University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Silver","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin K.","family":"Zinkhan","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara C.","family":"Heuser","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Nance","sequence":"additional","affiliation":[{"name":"Utah Birth Defects Network Utah Department of Health Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.022"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/2150135118787723"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200606000-00009"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.05.064"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-2577"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09246"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.385301.BE"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.120080"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.02.003"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.1811"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.3635"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13700"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-10-0077"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-011-0248-1"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx033"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12252"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.09.116"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4268"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy015"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32776-1"},{"key":"e_1_3_1_22_2","first-page":"515","article-title":"(2) Classification and diagnosis of diabetes","author":"American Diabetes A","year":"2015","unstructured":"American Diabetes A . (2) Classification and diagnosis of diabetes. Diabetes Care. 2015;515\u2013526.","journal-title":"Diabetes Care"},{"key":"e_1_3_1_23_2","volume-title":"Weight Gain During Pregnancy: Reexamining the Guidelines","author":"Institute of M and National Research Council Committee to Reexamine IOMPWG","year":"2009","unstructured":"Institute of M and National Research Council Committee to Reexamine IOMPWG . The National Academies Collection: reports funded by National Institutes of Health. In: Rasmussen KM, Yaktine AL, eds. Weight Gain During Pregnancy: Reexamining the Guidelines. Washington, DC: National Academies Press (US) National Academy of Sciences; 2009."},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/81.3.515"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12660"},{"key":"e_1_3_1_26_2","first-page":"E71","article-title":"The pulmonary circulation in the single ventricle patient","author":"Hauck A","year":"2017","unstructured":"Hauck A, Porta N, Lestrud S, Berger S. The pulmonary circulation in the single ventricle patient. Children (Basel). 2017;E71.","journal-title":"Children (Basel)"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174415001300"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01809.x"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.12.031"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10121917"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16010015"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00610.2016"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00127.2019"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00183.2010"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.937995"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2018.08.013"},{"key":"e_1_3_1_37_2","first-page":"349286","article-title":"Fetoplacental vascular endothelial dysfunction as an early phenomenon in the programming of human adult diseases in subjects born from gestational diabetes mellitus or obesity in pregnancy","author":"Leiva A","year":"2011","unstructured":"Leiva A, Pardo F, Ramirez MA, Farias M, Casanello P, Sobrevia L. Fetoplacental vascular endothelial dysfunction as an early phenomenon in the programming of human adult diseases in subjects born from gestational diabetes mellitus or obesity in pregnancy. Exp Diabetes Res. 2011;349286.","journal-title":"Exp Diabetes Res"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.08.003"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.06.013"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16461-8"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2443"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00629"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2012.12.005"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002428"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:29:42Z","timestamp":1715599782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.014363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,6,16]]}},"alternative-id":["10.1161\/JAHA.119.014363"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.014363","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]},"assertion":[{"value":"2020-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e014363"}}