{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:24:37Z","timestamp":1776975877070,"version":"3.51.4"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,3,3]]},"abstract":"\n Background<\/jats:title>\n \n Left bundle branch block (\n LBBB<\/jats:styled-content>\n ) is common after transcatheter aortic valve implantation (\n TAVI<\/jats:styled-content>\n ) and is an indicator of subsequent high\u2010grade atrioventricular block (\n HAVB<\/jats:styled-content>\n ). No standardized protocol is available to identify\n LBBB<\/jats:styled-content>\n patients at risk for\n HAVB<\/jats:styled-content>\n . The aim of the current study was to evaluate the safety and efficacy of an electrophysiology study tailored strategy in patients with\n LBBB<\/jats:styled-content>\n after\n TAVI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We prospectively analyzed consecutive patients with\n LBBB<\/jats:styled-content>\n after\n TAVI<\/jats:styled-content>\n . An electrophysiology study was performed to measure the\n HV<\/jats:styled-content>\n \u2010interval the day following\n TAVI<\/jats:styled-content>\n . In patients with normal His\u2010ventricular (\n HV<\/jats:styled-content>\n )\u2010interval \u226455\u00a0ms, a loop recorder was implanted (\n ILR<\/jats:styled-content>\n \u2010group), whereas pacemaker implantation was performed in patients with prolonged\n HV<\/jats:styled-content>\n \u2010interval >55\u00a0ms (\n PM<\/jats:styled-content>\n \u2010group). The primary end point was occurrence of\n HAVB<\/jats:styled-content>\n during a follow\u2010up of 12\u00a0months. Secondary end points were symptoms, hospitalizations, adverse events because of device implantation or electrophysiology study, and death. Of 373 patients screened after\n TAVI<\/jats:styled-content>\n , 56 patients (82\u00b16\u00a0years, 41% male) with\n LBBB<\/jats:styled-content>\n were included.\n HAVB<\/jats:styled-content>\n occurred in 4 of 41 patients (10%) in the\n ILR<\/jats:styled-content>\n \u2010group and in 8 of 15 patients (53%) in the\n PM<\/jats:styled-content>\n \u2010group (\n P<\/jats:italic>\n <0.001). We did not identify other predictors for\n HAVB<\/jats:styled-content>\n than the\n HV<\/jats:styled-content>\n interval. The negative predictive value for the cut\u2010off of\n HV<\/jats:styled-content>\n 55\u00a0ms to detect\n HAVB<\/jats:styled-content>\n was 90%. No\n HAVB<\/jats:styled-content>\n \u2010related syncope occurred in the 2 groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n An electrophysiology study tailored strategy to\n LBBB<\/jats:styled-content>\n after\n TAVI<\/jats:styled-content>\n with a cut\u2010off of\n HV<\/jats:styled-content>\n >55\u00a0ms is a feasible and safe approach to stratify patients with regard to developing\n HAVB<\/jats:styled-content>\n during a follow\u2010up of 12\u00a0months.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014446","type":"journal-article","created":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T10:00:25Z","timestamp":1582365625000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Electrophysiology Testing to Stratify Patients With Left Bundle Branch Block After Transcatheter Aortic Valve Implantation"],"prefix":"10.1161","volume":"9","author":[{"given":"Sven","family":"Knecht","sequence":"first","affiliation":[{"name":"Cardiology\/Electrophysiology University Hospital Basel University Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel University Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"Schaer","sequence":"additional","affiliation":[{"name":"Cardiology\/Electrophysiology University Hospital Basel University Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel University Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Reichlin","sequence":"additional","affiliation":[{"name":"Cardiology\/Electrophysiology University Hospital Basel University Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel University 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Hospital Basel University Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Fahrni","sequence":"additional","affiliation":[{"name":"Cardiology\/Electrophysiology University Hospital Basel University Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel University Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raban","family":"Jeger","sequence":"additional","affiliation":[{"name":"Cardiology\/Electrophysiology University Hospital Basel University Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel University Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Cardiology\/Electrophysiology University Hospital Basel University Basel Basel Switzerland"},{"name":"Cardiovascular Research 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Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel University Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.032"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.01.049"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht150"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.04.026"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.256578"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22567"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.035"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.03.008"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.07.012"},{"key":"e_1_3_2_12_2","first-page":"305","article-title":"Electrophysiological 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