{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:14:03Z","timestamp":1791522843950,"version":"4.3.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,3,3]]},"abstract":"\n Background<\/jats:title>\n Patients aged \u226590 were excluded or under\u2010represented in past thrombectomy trials; thus, uncertainty remains whether treatment benefits can be expected regardless of age. This study investigates outcome and safety of thrombectomy in nonagenarians to improve decision making in a real\u2010world setting.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n All currently available data of patients aged \u226590 enrolled in the GSR\u2010ET (German Stroke Registry\u2013Endovascular Treatment) were combined with a smaller cohort from 3 tertiary stroke centers. Baseline characteristics, procedural (Thrombolysis in Cerebral Infarction scale) and functional outcomes (modified Rankin Scale;\n mRS<\/jats:styled-content>\n ), as well as complications (symptomatic intracranial hemorrhage, serious adverse events; SAEs) were analyzed. Good functional outcome was defined as\n mRS<\/jats:styled-content>\n \u22643 at 90\u2010days. 203 patients with anterior circulation stroke and prestroke\n mRS<\/jats:styled-content>\n \u22643 were included. The rate of successful recanalization (Thrombolysis in Cerebral Infarction scale \u22652b) was 75.9% (154\/203). Good functional outcome (\n mRS<\/jats:styled-content>\n \u22643) was observed in 21.6% (41 of 193) at 90\u2010days. In\u2010hospital mortality was 27.1% (55 of 203) and increased significantly at 90 days to 48.9% (93 of 190;\n P<\/jats:italic>\n <0.001). Symptomatic intracranial hemorrhage occurred in 3% (6 of 203) of patients. Logistic regression analysis identified Alberta Stroke Program Early CT Score (adjusted odds ratio, 1.93; 95%\n CI<\/jats:styled-content>\n , 1.01\u20133.70;\n P<\/jats:italic>\n =0.046) and initial National Institute of Health Stroke Scale (adjusted odds ratio, 0.85; 95%\n CI<\/jats:styled-content>\n , 0.76\u20130.97;\n P<\/jats:italic>\n =0.014) as independent predictors for good outcome. Patients with successful recanalization had a significant (\n P<\/jats:italic>\n =0.001) shift of\n mRS<\/jats:styled-content>\n distribution with higher rates of good functional outcomes (23.8% [34 of 143] versus 14.9% [7 of 47]) and lower mortality at 90\u2010days (46.8% [67 of 143] versus 55.3% [26 of 47]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Despite high mortality and less frequent favorable outcome, our data suggest that thrombectomy is still effective and safe for nonagenarians. Decision making for thrombectomy in patients aged \u226590 should be based on a case\u2010by\u2010case basis with regard to initial National Institute of Health Stroke Scale and Alberta Stroke Program Early CT Score.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014447","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T10:00:22Z","timestamp":1582538422000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["Endovascular Treatment of Very Elderly Patients Aged \u226590 With Acute Ischemic Stroke"],"prefix":"10.1161","volume":"9","author":[{"given":"Lukas","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University Medical Center Hamburg\u2010Eppendorf Hamburg 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